Vitamin A ： Acute Diarrhea

Some evidence in vitamin A-deficient populations. WHO recommends for measles-associated diarrhea. Not effective in non-deficient individuals.

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結論

Some evidence in vitamin A-deficient populations. WHO recommends for measles-associated diarrhea. Not effective in non-deficient individuals.

Key Study Findings

Review

The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; …

Dose: None vs: None Outcome: None 効果: None None

対象集団: children with persistent diarrhea, lactose intolerance, and gut dysbiosis in low/middle-income countries

Other 12 weeks

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics.

Dose: None vs: HFD control mice Outcome: NAFLD biomarkers and gut microbiota composition 効果: None None

対象集団: HFD-induced NAFLD mouse model

Review

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.

Dose: None vs: None Outcome: Athletic performance and nutritional optimization 効果: None None

対象集団: Vegan athletes (narrative review)

Observational Study

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions …

Dose: None vs: None Outcome: DALYs and mortality rates of congenital birth defects 効果: DALYs decreased 59.77%, deaths decreased 63.81% None

対象集団: G20 countries population, 1990-2021

Review

B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency.

Dose: B vitamins and glucuronolactone vs: None Outcome: Immune system function 効果: None None

対象集団: General population (review)

Observational Study n=48

The Resurgence of Measles Infection and its Associated Complications in Early Childhood at a Tertiary …

Dose: None vs: None Outcome: None 効果: None None

対象集団: Children with acute diarrhea

Key Statistics

研究数

500

参加者数

↑

Positive

グレード

Referenced Papers

The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; a comprehensive review. Other

BMC pediatrics 2026

Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040. Other

BMC pregnancy and … 2025 6 件の引用

Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review. Review

Current nutrition reports 2025 3 件の引用

Revealing the mechanism of Ganoderma lucidum insoluble dietary fiber alleviating NAFLD through transcriptomics and metabolomics. Other

NPJ science of … 2025 2 件の引用

B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency. Review

Nutrients 2023 21 件の引用

The Resurgence of Measles Infection and its Associated Complications in Early Childhood at a Tertiary Care Hospital in Peshawar, Pakistan. Other

Polish journal of … 2020 14 件の引用

[Skin Manifestations of Pellagra]. Other

Brain and nerve … 2019 1 件の引用

Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis. Meta-Analysis

PloS one 2018 76 件の引用

Interventions to reduce post-acute consequences of diarrheal disease in children: a systematic review. Systematic Review

BMC public health 2018 23 件の引用

Diet and nutritional factors in inflammatory bowel diseases. Review

World journal of … 2016 238 件の引用

Nutrition and skin: Kids are not just little people. Review

Clinics in dermatology 2016 19 件の引用

The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children: protocol for a systematic review … Other

Systematic reviews 2016

Maternal agency influences the prevalence of diarrhea and acute respiratory tract infections among young Indonesian children. Other

Maternal and child … 2015 23 件の引用

Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study. Other

Medical journal of … 2015 15 件の引用

Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. Other

Journal of pediatric … 2014 38 件の引用

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 件の引用

Zinc supplementation in burn patients. Other

Journal of burn … 2012 16 件の引用

Zinc, vitamin A, and micronutrient supplementation in children with diarrhea: a randomized controlled clinical trial of combination therapy versus monotherapy. RCT

The Journal of … 2011 30 件の引用

Interaction of zinc or vitamin A supplementation and specific parasite infections on Mexican infants' growth: a randomized clinical trial. RCT

European journal of … 2009 24 件の引用

Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. Other

American journal of … 2008 25 件の引用

Effect of infections and environmental factors on growth and nutritional status in developing countries. Other

Journal of pediatric … 2006 54 件の引用

Human immunodeficiency virus infection, diarrheal disease and sociodemographic predictors of child growth. Other

Acta paediatrica (Oslo, … 2004 38 件の引用

Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. Review

Biometals : an … 2004 36 件の引用

Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. Other

Journal of health, … 2003

The immune system: a target for functional foods? Review

The British journal … 2002 358 件の引用

Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. RCT

Pediatrics 2002 154 件の引用

Micronutrient deficiency in children. Other

The British journal … 2001 74 件の引用

The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. RCT

Journal of pediatric … 2001 56 件の引用

Micronutrients as adjunct therapy of acute illness in children: impact on the episode outcome and policy implications of current findings. Other

The British journal … 2001 30 件の引用

Oxidative stress is not enhanced in non-malnourished infants with persistent diarrhea. Other

Journal of tropical … 2001 8 件の引用

Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. RCT

The Journal of … 2000 107 件の引用

Vitamin A supplementation in acute diarrhea. RCT

Journal of pediatric … 2000 20 件の引用

Vitamin A supplementation of South African children with severe diarrhea: optimum timing for improving biochemical and clinical recovery and subsequent … RCT

The Pediatric infectious … 2000 14 件の引用

[Nutrient utilization in children with acute diarrhea fed with formulas containing chicken and soybean]. Other

Archivos latinoamericanos de … 1999 3 件の引用

Urinary excretion and plasma vitamin E levels in patients with AIDS. Other

Nutrition (Burbank, Los … 1998 24 件の引用

Chronic diarrhea in infancy and childhood. Review

The Journal of … 1998 3 件の引用

"Feeding the gut": the scientific basis for continued enteral nutrition during acute diarrhea. Review

The Journal of … 1997 48 件の引用

Breast-feeding status alters the effect of vitamin A treatment during acute diarrhea in children. RCT

The Journal of … 1997 28 件の引用

Urinary excretion of retinol in children with acute diarrhea. Other

The American journal … 1995 103 件の引用

A randomized controlled trial of vitamin A supplementation in acute diarrhea. RCT

Indian pediatrics 1995 31 件の引用

Impact of massive dose of vitamin A given to preschool children with acute diarrhoea on subsequent respiratory and diarrhoeal morbidity. RCT

BMJ (Clinical research … 1994 105 件の引用

Association of diarrhea and low serum retinol in Peruvian children. Other

The American journal … 1993 42 件の引用

Bangladesh women scientists' association honours ICDDR,B scientist. Other

Glimpse (Dhaka, Bangladesh) 1984

Change in serum vitamin A concentration after an oral dose in children with acute diarrhea. Other

The Journal of … 1983 16 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 700-900 mcg RAE/day (RDA for adults)
gutbarriersupport:: 900 mcg RAE/day from mixed sources
deficiencycorrection:: 200,000 IU single dose (WHO protocol for severe deficiency, medical supervision)

上限量： 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)

研究で検討された用量

用量	期間	効果	N
None	--	Neutral	--
None	12 weeks	Positive	--
None	--	Positive	--
None	--	Positive	--
B vitamins and glucuronolactone	--	Positive	--
None	--	Mixed	48
None	--	Mixed	--
None	1.0 weeks	Mixed	--

推奨摂取タイミング： With meals containing fat for better absorption

Safety & Side Effects

報告されている副作用

⚠ Hepatotoxicity at chronic high doses of preformed vitamin A
⚠ Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day)
⚠ Nausea, headache, and dizziness
⚠ Bone density reduction with long-term excess

既知の相互作用

● Retinoid medications (isotretinoin, tretinoin — additive toxicity risk)
● Orlistat (reduces absorption of fat-soluble vitamins)
● Alcohol (increases hepatotoxicity risk of vitamin A)
● Tetracycline antibiotics (increased risk of intracranial pressure)

耐容上限摂取量： 3,000 mcg RAE/day (preformed vitamin A; beta-carotene has no established UL)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Vitamin A help with Acute Diarrhea?

Based on 3 studies with 500 participants, there is preliminary evidence that needs more research that Vitamin A may support Acute Diarrhea management. Our evidence grade is D (Very Early Research).

How much Vitamin A should I take for Acute Diarrhea?

Studies have used various dosages. A commonly studied range is 700-900 mcg RAE/day (RDA for adults). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin A?

Reported side effects may include Hepatotoxicity at chronic high doses of preformed vitamin A, Birth defects (teratogenic at high doses during pregnancy — avoid >3,000 mcg RAE/day), Nausea, headache, and dizziness, Bone density reduction with long-term excess. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin A and Acute Diarrhea?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Acute Diarrhea

Zinc A Berberine C Bovine Colostrum D

Vitamin A 他の症状・状態について

Increased Intestinal Permeability (Leaky Gut) C

総合評価

Some evidence in vitamin A-deficient populations. WHO recommends for measles-associated diarrhea. Not effective in non-deficient individuals.

Evidence Strength30%

Low confidence

研究の内訳

RCT (10)Meta (1)Other (0)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Acute Diarrhea

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。