Deglycyrrhizinated Licorice (DGL) ： Functional Dyspepsia

Traditional use supported by limited clinical data. GutGard (DGL extract) showed improvement in functional dyspepsia symptoms in small RCTs.

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結論

Traditional use supported by limited clinical data. GutGard (DGL extract) showed improvement in functional dyspepsia symptoms in small RCTs.

Key Study Findings

Systematic Review

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

Dose: None vs: None Outcome: None 効果: None None

対象集団: the presence of dyspepsia in the absence of organic or metabolic causes

In Vitro

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive …

Dose: Glycyrrhiza glabra flavonoid-rich extract vs: None Outcome: compatibility with probiotics and digestive enzymes 効果: compatible with all tested strains None

対象集団: Probiotic strains and enzymes (in vitro)

Randomized Controlled Trial 4 weeks Double-blind

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled …

Dose: 75 mg twice daily vs: Placebo Outcome: Functional dyspepsia symptom severity (SFLDQ) 効果: None None

対象集団: Adults with functional dyspepsia

Key Statistics

研究数

200

参加者数

↑

Positive

グレード

Referenced Papers

Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. Systematic Review

Current drug discovery … 2021 16 件の引用

Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. Other

Journal of dietary … 2017 13 件の引用

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Other

Evidence-based complementary and … 2012 70 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 380-760 mg DGL extract 3 times daily before meals
gastricsupport:: 760 mg before meals and at bedtime
dyspepsiasupport:: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

上限量： Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
Glycyrrhiza glabra flavonoid-rich extract	--	Positive	--
75 mg twice daily	4 weeks	Positive	--

推奨摂取タイミング： 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Safety & Side Effects

報告されている副作用

⚠ Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
⚠ Mild nausea in rare cases
⚠ Headache (uncommon)
⚠ If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

既知の相互作用

● Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
● Diuretics (if residual glycyrrhizin, additive potassium loss)
● Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
● Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

耐容上限摂取量： Not established for DGL specifically; DGL removes the toxic glycyrrhizin component

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Deglycyrrhizinated Licorice (DGL) help with Functional Dyspepsia?

Based on 3 studies with 200 participants, there is limited but promising evidence that Deglycyrrhizinated Licorice (DGL) may support Functional Dyspepsia management. Our evidence grade is C (Some Evidence).

How much Deglycyrrhizinated Licorice (DGL) should I take for Functional Dyspepsia?

Studies have used various dosages. A commonly studied range is 380-760 mg DGL extract 3 times daily before meals. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Deglycyrrhizinated Licorice (DGL)?

Reported side effects may include Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Deglycyrrhizinated Licorice (DGL) and Functional Dyspepsia?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Functional Dyspepsia

Ginger B Bifidobacterium bifidum C

Deglycyrrhizinated Licorice (DGL) 他の症状・状態について

Peptic Ulcer Disease C

総合評価

Traditional use supported by limited clinical data. GutGard (DGL extract) showed improvement in functional dyspepsia symptoms in small RCTs.

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (0)Meta (0)Other (3)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Functional Dyspepsia

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。