エビデンスに基づいた サプリメントレビュー
Every gut claim cited.
We read the gut health studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Bifidobacterium longum
probiotic_strainFerments complex carbohydrates producing acetate and lactate that lower colonic pH; reduces visceral hypersensitivity via serotonin pathway modulation; downregulates pro-inflammatory …
Bacillus coagulans
probiotic_strainSpore-forming probiotic that survives gastric acid, bile salts, and heat; produces L(+)-lactic acid in the colon lowering pH and inhibiting …
Curcumin
herbInhibits NF-kB and COX-2 inflammatory cascades in intestinal mucosa reducing pro-inflammatory cytokine production; enhances mucosal healing through TGF-beta signaling; modulates …
Zinc
mineralEssential cofactor for intestinal alkaline phosphatase detoxifying bacterial endotoxin (LPS); maintains tight junction integrity via claudin and occludin expression; supports …
Vitamin D
vitaminBinds VDR receptors on intestinal epithelial cells enhancing tight junction protein expression (claudin-2, -12, -15); modulates mucosal immune response via …
Bifidobacterium lactis
probiotic_strainModulates intestinal immune response via NK cell activation and enhanced phagocytic activity; improves colonic transit time in a dose-dependent manner; …
Top Conditions
Gastroesophageal Reflux Disease (GERD)
20-30% in Western populations; 5-10% in Asia
Chronic Constipation
15-20% of adults globally; increases with age; more common in women
Acute Diarrhea
1.7 billion cases of childhood diarrhea globally per year; 525,000 deaths
Antibiotic-Associated Diarrhea (AAD)
5-39% of antibiotic users; varies by antibiotic class
Clostridioides difficile Infection (CDI)
500,000 infections/year in the US; 29,000 deaths
Ulcerative Colitis (UC)
~0.3% in Western countries; peak onset 15-30 years
Recent Evidence Updates
3 件の研究
4 件の研究
3 件の研究
3 件の研究
4 件の研究
Popular Comparisons
Latest Research
Front Immunol · 2019
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.
Am J Clin Nutr · 1991
Omega-3 fatty acids in health and disease and in growth and development.
J Am Coll Nutr · 2002
Omega-3 fatty acids in inflammation and autoimmune diseases.
AAPS J · 2013
Therapeutic roles of curcumin: lessons learned from clinical trials.
Proc Natl Acad Sci … · 2014
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.
Gut · 2014
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.
Guides & Resources
Managing Stress-Related Gut Issues: The Mind-Body Connection in Digestive Health
The intimate connection between psychological stress and digestive symptoms is a common lived experience — the butterflies before a presentation, the loss of appetite during …
lifestyleDiet and Gut Health: Evidence-Based Nutritional Strategies for Digestive Wellness
Diet is widely recognized as one of the most powerful modulators of the gut microbiome, with research demonstrating that dietary changes can alter microbial composition …
safetyDigestive Enzyme Supplements: Types, Timing, and Safe Use
Digestive enzymes are proteins produced naturally by the body to break down food into absorbable nutrients. The major categories include proteases that break down proteins, …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
広告なし。スポンサーランキングなし。科学だけ。
リサーチハブ
サプリメント成分に関するすべての臨床研究を PubMed で検索しています。
抽出
主要な知見（サンプルサイズ、研究タイプ、結果）を抽出しています。
グレード A から F
エビデンスを通知表のようにグレード付けします — A（強い）から F（否定的）まで。
明確な答え
数秒で明確な答えが得られます — このサプリメントは実際に効果が期待できるのか？
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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。