What is the recommended dosage for Bifidobacterium longum?

General: 1-10 billion CFU/day; Ibs Support: 1 billion CFU/day (35624 strain, marketed as Alflorex/Align)

What are the side effects of Bifidobacterium longum?

Potential side effects include: Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals.

What is Bifidobacterium longum and how does it work for gut health?

Bifidobacterium longum is one of the first bacteria to colonize the human gut after birth and remains present throughout life. It produces short-chain fatty acids, helps metabolize bile acids, and may reduce intestinal inflammation. Research suggests it may also influence the gut-brain axis, potentially supporting both digestive and mental well-being.

What is the recommended dosage of Bifidobacterium longum?

Studies have used dosages from 1 billion to 50 billion CFU per day. The strain B. longum 35624 (Alflorex/Align) has been studied extensively at approximately 1 billion CFU daily for IBS symptoms. Other strains like BB536 have been used at 2-5 billion CFU per day with positive results.

Are there side effects or interactions with Bifidobacterium longum?

Bifidobacterium longum is well-tolerated with a strong safety profile established across many clinical trials. Minor gastrointestinal symptoms such as increased gas may occur initially but typically resolve within a few days. There are no widely documented drug interactions, though standard precautions apply for immunocompromised individuals.

Bifidobacterium longum

probiotic_strain

Also known as: B. longum, Bifidobacterium longum subsp. longum, BB536, 35624, Alflorex, Align

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About

Bifidobacterium longum is a key commensal bacterium in the healthy human gut, present from birth and throughout life. It supports digestive health by fermenting complex carbohydrates to produce acetate and lactate, which may help maintain a healthy colonic environment. Research suggests the 35624 strain may help reduce visceral hypersensitivity through serotonin pathway modulation, supporting digestive comfort.

How It Works

Ferments complex carbohydrates producing acetate and lactate that lower colonic pH; reduces visceral hypersensitivity via serotonin pathway modulation; downregulates pro-inflammatory cytokines (IL-6, TNF-alpha); enhances regulatory T cell activity in gut-associated lymphoid tissue.

Evidence For Conditions

Condition	Grade	Studies	Participants
Irritable Bowel Syndrome (IBS)	B	4	600	View →

Side Effects

Mild gas and bloating during initial use
Occasional abdominal discomfort
Rare loose stools
Very rare: bacteremia in immunocompromised individuals

Drug & Supplement Interactions

Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
Immunosuppressants (use with caution in immunocompromised patients)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bacillus coagulans Bifidobacterium bifidum Bifidobacterium breve Bifidobacterium lactis Lactobacillus acidophilus

Quick Facts

Dosage: General: 1-10 billion CFU/day; Ibs_Support: 1 billion CFU/day (35624 strain, marketed as Alflorex/Align)
Forms: capsule powder sachet
Natural Sources: Human GI tract (commensal from birth), Breast milk, Fermented dairy products
Upper Limit: Well-tolerated up to 10 billion CFU/day in clinical trials
Best Time: On an empty stomach or before meals

Evidence Summary

Irritable Bowel Syndrome (IBS) B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.