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Berberine pour Small Intestinal Bacterial Overgrowth (SIBO)

C

Herbal antimicrobial protocol including berberine showed comparable efficacy to rifaximin for SIBO in retrospective study. Prospective RCT data limited.

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            C

        

        

            
En conclusion

            
            
Herbal antimicrobial protocol including berberine showed comparable efficacy to rifaximin for SIBO in retrospective study. Prospective RCT data limited.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Meta-Analysis
                
                
                n=1552
                
                
                
            

            
                Comparative efficacy of diverse therapeutic regimens for small intestinal bacterial overgrowth: a systematic network meta-analysis.
            
            

                
                Dose: None
                
                
                vs: Multiple comparators (network meta-analysis)
                
                
                Outcome: SIBO eradication rate
                
                
                Effet: Berberine highest SUCRA
                
                
                None
                
            

            
            
Population: Adults with SIBO from 30 RCTs

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                2 weeks
                
                
                Open-label
                
            

            
                Berberine and rifaximin effects on small intestinal bacterial overgrowth: Study protocol for an investigator-initiated, double-arm, …
            
            

                
                Dose: 400 mg d
                
                
                vs: control
                
                
                Outcome: a negative breath test
                
                
                Effet: None
                
                
                None
                
            

            
            
Population: Long-term abdominal discomfort and avoiding excessive examination

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Études

    

    

        
180

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Note

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Comparative efficacy of diverse therapeutic regimens for small intestinal bacterial overgrowth: a systematic network meta-analysis.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Therapeutic advances in …
                        2025
                        
                    

                

                
                

                    

                        
                            Berberine and rifaximin effects on small intestinal bacterial overgrowth: Study protocol for an investigator-initiated, double-arm, open-label, randomized clinical trial (BRIEF-SIBO …
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Frontiers in pharmacology
                        2023
                        
                        8 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Posologies couramment utilisées

                

                    
                    

                        
general:

                        
500-1,500 mg/day in divided doses

                    

                    
                    

                        
siboprotocol:

                        
500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol)

                    

                    
                    

                        
giantimicrobial:

                        
500 mg twice daily

                    

                    
                

                
                

                    Limite supérieure : Generally well-tolerated up to 1,500 mg/day in divided doses
                

                
            

            

            
            

                
Posologies étudiées dans la recherche

                

                    

                        
                            

                                Posologie
                                Durée
                                Effet
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                1552
                            

                            
                            

                                400 mg d
                                2 weeks
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Moment optimal de prise : With meals; divide doses throughout the day (do not take full daily dose at once)
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effets indésirables signalés

                    
    
                        
                        
  • 
                            ⚠
                            GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
                        
    • 
                        
                        
  • 
                            ⚠
                            May cause uterine contractions (contraindicated in pregnancy)
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                        
  • 
                            ⚠
                            Skin rash (rare)
                        
    • 
                        
                    

                

                

                
                

                    
Interactions connues

                    
    
                        
                        
  • 
                            ●
                            Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
                        
    • 
                        
                        
  • 
                            ●
                            Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may have additive blood-thinning effects)
                        
    • 
                        
                        
  • 
                            ●
                            Metformin (additive glucose-lowering effect; monitor closely)
                        
    • 
                        
                        
  • 
                            ●
                            Macrolide antibiotics (berberine inhibits CYP3A4)
                        
    • 
                        
                    

                

                

                
                

                    

                        Apport maximal tolérable : Generally well-tolerated up to 1,500 mg/day in divided doses
                    

                

                
            

            

                Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Berberine help with Small Intestinal Bacterial Overgrowth (SIBO)?
            
        
        

            Based on 2 studies with 180 participants, there is limited but promising evidence that Berberine may support Small Intestinal Bacterial Overgrowth (SIBO) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Berberine should I take for Small Intestinal Bacterial Overgrowth (SIBO)?
            
        
        

            Studies have used various dosages. A commonly studied range is 500-1,500 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Berberine?
            
        
        

            Reported side effects may include GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Berberine and Small Intestinal Bacterial Overgrowth (SIBO)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 180 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Autres ingrédients pour Small Intestinal Bacterial Overgrowth (SIBO)

                    

                        
                        
                            Partially Hydrolyzed Guar Gum (PHGG)
                            C

                        
                        
                    

                

                

                
                

                    
Berberine pour d'autres pathologies

                    

                        
                        
                            Acute Diarrhea
                            C

                        
                        
                        
                            Gut Dysbiosis
                            D

                        
                        
                    

                

                
            

        

        

    


    
    












    

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        Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.