Zinc Carnosine for Peptic Ulcer Disease

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

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The Bottom Line

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

Key Study Findings

Randomized Controlled Trial n=92

Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A …

Dose: Zinc carnosine 75 mg twice daily for 10 days vs: Standard triple therapy for 14 days Outcome: H. pylori eradication rate Effect: 93.5% vs 69.6% P=0.003

Population: Dyspepsia patients with H. pylori infection

In Vitro

The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats.

Dose: 30 mg/kg vs: None Outcome: mineral status Effect: or 2 None

Population: animal model

Key Statistics

Studies

500

Participants

↑

Positive

Grade

Referenced Papers

Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled study. Other

World journal of … 2022 8 citations

The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats. Other

Life sciences 1991 52 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:: 75 mg twice daily (as zinc carnosine complex)
nsaidprotection:: 37.5-75 mg twice daily alongside NSAID therapy
gastricprotection:: 75 mg twice daily for 8 weeks

Upper limit: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this

Dosages Studied in Research

Dosage	Duration	Effect	N
Zinc carnosine 75 mg twice daily for 10 days	--	Positive	92
30 mg/kg	--	Positive	--

Best taken: On an empty stomach or between meals for gastric mucosal contact; twice daily

Safety & Side Effects

Reported Side Effects

⚠ Nausea (most common, usually transient)
⚠ Metallic taste
⚠ Copper depletion with long-term high-dose use (>40 mg elemental zinc/day)
⚠ Headache

Known Interactions

● Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
● Penicillamine (zinc reduces absorption)
● Copper supplements (zinc competes with copper for absorption)
● Bisphosphonates (zinc may reduce absorption; space 2 hours)

Tolerable upper intake: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Zinc Carnosine help with Peptic Ulcer Disease?

Based on 6 studies with 500 participants, there is moderate evidence from clinical studies that Zinc Carnosine may support Peptic Ulcer Disease management. Our evidence grade is B (Good Evidence).

How much Zinc Carnosine should I take for Peptic Ulcer Disease?

Studies have used various dosages. A commonly studied range is 75 mg twice daily (as zinc carnosine complex). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zinc Carnosine?

Reported side effects may include Nausea (most common, usually transient), Metallic taste, Copper depletion with long-term high-dose use (>40 mg elemental zinc/day), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zinc Carnosine and Peptic Ulcer Disease?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

Other ingredients for Peptic Ulcer Disease

Deglycyrrhizinated Licorice (DGL) C

Zinc Carnosine for other conditions

Increased Intestinal Permeability (Leaky Gut) C

Quick Verdict

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

Evidence Strength72%

High confidence

Study Breakdown

RCT (0)Meta (0)Other (6)

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.