Skip to main content
GutCited

Aloe Vera (Inner Leaf Gel) para Ulcerative Colitis (UC)

D

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'ingredient\u003Daloe\u002Dvera\u0026condition\u003Dibd\u002Dulcerative\u002Dcolitis'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    

Widget powered by . Free, no account required.

D

Conclusión

Single RCT showed aloe vera gel improved UC symptoms vs placebo. Very limited evidence; not replicated.

Key Study Findings

Review
Emerging Natural Therapies for the Treatment of Inflammatory Bowel Disease.
Dose: None vs: None Outcome: None Efecto: None None

Población: Review of natural therapies for IBD

In Vitro 1.0 weeks
Therapeutic Effects of Aloe saponaria against Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Dose: 272 µg/ vs: vehicle Outcome: Ulcerative colitis severity Efecto: None None

Población: Mice (DSS-induced colitis model)

Controlled Clinical Trial n=36 2 weeks
Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats.
Dose: 20, 40, or 60 mg/kg b.wt. vs: Dexamethasone 1 mg/kg and normal saline Outcome: Clinical activity index, histological alterations, DNA, NO Efecto: None None

Población: Adult male Wistar rats with acetic acid-induced UC

Review
Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes.
Dose: None vs: None Outcome: None Efecto: None None

Población: Ulcerative colitis patients using CAM

Other
Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing …
Dose: None vs: None Outcome: None Efecto: None None

Población: None

Controlled Clinical Trial
Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats.
Dose: None vs: Control without aloe vera Outcome: Anti-inflammatory, antioxidant, wound healing Efecto: None None

Población: Animal/cell wound healing models

Key Statistics

1

Estudios

44

Participantes

Positive

D

Calificación

Referenced Papers

Current pharmaceutical biotechnology 2025 1 citas
Annals of gastroenterology 2015 135 citas
Alimentary pharmacology & … 2013 128 citas
Saudi journal of … 2012 138 citas
Health news (Waltham, … 2004 1 citas
The European journal … 1998 62 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:
100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule
ibssupport:
100 mL twice daily for 1-3 months
constipation:
100-300 mg aloe latex (short-term only, maximum 1-2 weeks)

Límite superior: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Dosificaciones estudiadas en la investigación

Dosificación Duración Efecto N
None -- Mixed --
272 µg/ 1.0 weeks Positive --
20, 40, or 60 mg/kg b.wt. 2 weeks Positive 36
None -- Mixed --
None -- Mixed --
None -- Positive --
None -- Positive --
2 g 3 weeks Positive --

Mejor momento para tomar: Before meals; aloe latex should only be used short-term for constipation

Safety & Side Effects

Efectos secundarios reportados

  • Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products)
  • Electrolyte imbalance (hypokalemia) with chronic laxative use
  • Potential hepatotoxicity with long-term whole leaf consumption (rare)
  • Allergic skin reactions in sensitive individuals

Interacciones conocidas

  • Digoxin (hypokalemia from laxative use may increase digoxin toxicity)
  • Diuretics (additive potassium loss with aloe latex)
  • Diabetes medications (aloe may lower blood sugar; monitor glucose)
  • Stimulant laxatives (additive laxative effect; avoid combining)
  • Anticoagulants (theoretical interaction due to platelet effects)

Ingesta máxima tolerable: No established UL for inner leaf gel; aloe latex (anthraquinones) should be limited to 1-2 weeks

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Aloe Vera (Inner Leaf Gel) help with Ulcerative Colitis (UC)?
Based on 1 studies with 44 participants, there is preliminary evidence that needs more research that Aloe Vera (Inner Leaf Gel) may support Ulcerative Colitis (UC) management. Our evidence grade is D (Very Early Research).
How much Aloe Vera (Inner Leaf Gel) should I take for Ulcerative Colitis (UC)?
Studies have used various dosages. A commonly studied range is 100-200 mL aloe vera inner leaf gel/juice per day, or 300-500 mg capsule. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Aloe Vera (Inner Leaf Gel)?
Reported side effects may include Diarrhea and abdominal cramps (especially with aloe latex/whole leaf products), Electrolyte imbalance (hypokalemia) with chronic laxative use, Potential hepatotoxicity with long-term whole leaf consumption (rare), Allergic skin reactions in sensitive individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Aloe Vera (Inner Leaf Gel) and Ulcerative Colitis (UC)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 44 total participants. The overall direction of effect is positive.

Related Evidence

Aloe Vera (Inner Leaf Gel) para otras condiciones

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.