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Zinc Carnosine für Peptic Ulcer Disease

B

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

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B

Fazit

Reduces NSAID-induced small bowel injury by 70% (measured by calprotectin). Promotes gastric mucosal healing. 75-150 mg/day as zinc carnosine complex.

Key Study Findings

Randomized Controlled Trial n=92
Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A …
Dose: Zinc carnosine 75 mg twice daily for 10 days vs.: Standard triple therapy for 14 days Outcome: H. pylori eradication rate Wirkung: 93.5% vs 69.6% P=0.003

Population: Dyspepsia patients with H. pylori infection

In Vitro
The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats.
Dose: 30 mg/kg vs.: None Outcome: mineral status Wirkung: or 2 None

Population: animal model

Key Statistics

6

Studien

500

Teilnehmer

Positive

B

Bewertung

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
75 mg twice daily (as zinc carnosine complex)
nsaidprotection:
37.5-75 mg twice daily alongside NSAID therapy
gastricprotection:
75 mg twice daily for 8 weeks

Obergrenze: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
Zinc carnosine 75 mg twice daily for 10 days -- Positive 92
30 mg/kg -- Positive --

Beste Einnahmezeit: On an empty stomach or between meals for gastric mucosal contact; twice daily

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Nausea (most common, usually transient)
  • Metallic taste
  • Copper depletion with long-term high-dose use (>40 mg elemental zinc/day)
  • Headache

Bekannte Wechselwirkungen

  • Tetracycline and quinolone antibiotics (zinc reduces absorption; space 2 hours)
  • Penicillamine (zinc reduces absorption)
  • Copper supplements (zinc competes with copper for absorption)
  • Bisphosphonates (zinc may reduce absorption; space 2 hours)

Tolerierbare Höchstaufnahmemenge: 40 mg/day elemental zinc (equivalent to ~340 mg zinc carnosine); risk of copper depletion above this

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Zinc Carnosine help with Peptic Ulcer Disease?
Based on 6 studies with 500 participants, there is moderate evidence from clinical studies that Zinc Carnosine may support Peptic Ulcer Disease management. Our evidence grade is B (Good Evidence).
How much Zinc Carnosine should I take for Peptic Ulcer Disease?
Studies have used various dosages. A commonly studied range is 75 mg twice daily (as zinc carnosine complex). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc Carnosine?
Reported side effects may include Nausea (most common, usually transient), Metallic taste, Copper depletion with long-term high-dose use (>40 mg elemental zinc/day), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc Carnosine and Peptic Ulcer Disease?
We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

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