N-Acetyl Cysteine (NAC) für Inflammatory Bowel Disease (IBD) — General

Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.

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Fazit

Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.

Key Study Findings

Review

Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases.

Dose: None vs.: None Outcome: None Wirkung: None None

Population: Review of nanocatalytic antioxidation in diseases

Randomized Controlled Trial 16 weeks Open-label

Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury …

Dose: N-acetylcysteine with thiopurine vs.: Thiopurine alone (crossover) Outcome: Liver injury markers and oxidative stress Wirkung: None None

Population: IBD patients with thiopurine-induced liver injury

Review

The emerging role of oxidative stress in inflammatory bowel disease.

Dose: None vs.: None Outcome: Oxidative stress role in IBD pathophysiology Wirkung: None None

Population: IBD patients (Crohn's and UC)

In Vitro 4.3 weeks

Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney.

Dose: 150 mg/kg vs.: None Outcome: inflammation markers Wirkung: None None

Population: Mice

Systematic Review 52 weeks

Vitamin D for the treatment of inflammatory bowel disease.

Dose: 400 IU/day vs.: placebo Outcome: IBD disease activity Wirkung: None None

Population: Patients with IBD

Review

Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease …

Dose: None vs.: None Outcome: Ferroptosis role in IBD pathogenesis Wirkung: None None

Population: IBD patients (mechanistic review)

Key Statistics

Studien

Teilnehmer

↑

Positive

Bewertung

Referenced Papers

Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. Review

Accounts of chemical … 2025 2 Zitierungen

The emerging role of oxidative stress in inflammatory bowel disease. Review

Frontiers in endocrinology 2024 165 Zitierungen

Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury in inflammatory bowel disease: A … RCT

Basic & clinical … 2024

Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review). Review

International journal of … 2023 59 Zitierungen

Potential Use of Antioxidant Compounds for the Treatment of Inflammatory Bowel Disease. Review

Pharmaceuticals (Basel, Switzerland) 2023 18 Zitierungen

Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney. Other

Oxidative medicine and … 2023 11 Zitierungen

Vitamin D for the treatment of inflammatory bowel disease. Systematic Review

The Cochrane database … 2023 1 Zitierungen

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy. Other

Journal of nanobiotechnology 2022 206 Zitierungen

High-fructose corn syrup promotes proinflammatory Macrophage activation via ROS-mediated NF-κB signaling and exacerbates colitis in mice. Other

International immunopharmacology 2022 21 Zitierungen

Moronic acid improves intestinal inflammation in mice with chronic colitis by inhibiting intestinal macrophage polarization. Other

Journal of biochemical … 2022 5 Zitierungen

Vitamin D supplementation in inflammatory bowel disease: a narrative review. Review

Medwave 2022 4 Zitierungen

Diet supporting therapy for inflammatory bowel diseases. Review

European journal of … 2021 40 Zitierungen

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation. Other

Journal of inflammation … 2021 34 Zitierungen

Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis. Other

Journal of Crohn's … 2018 91 Zitierungen

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis. Other

Redox biology 2017 34 Zitierungen

Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease. Other

Digestion 2016 522 Zitierungen

Role of oxidative stress mediated by glutathione-s-transferase in thiopurines' toxic effects. Other

Chemical research in … 2015 13 Zitierungen

N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats. Other

Scandinavian journal of … 2013 65 Zitierungen

Omega-3 fatty acids and inflammatory bowel diseases - a systematic review. Systematic Review

The British journal … 2012 145 Zitierungen

Impact of environmental and dietary factors on the course of inflammatory bowel disease. Review

World journal of … 2012 113 Zitierungen

Chios mastic, a natural supplement for zinc to enhance male sexuality and prostate function. Other

Pharmaceutical biology 2010 16 Zitierungen

Effect of N-acetylcysteine on the murine model of colitis induced by dextran sodium sulfate through up-regulating PON1 activity. Other

Digestive diseases and … 2009 49 Zitierungen

Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Other

Molecular and cellular … 2007 95 Zitierungen

Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. Other

Journal of agricultural … 2007 44 Zitierungen

Beneficial effects of N-acetylcysteine on acetic acid-induced colitis in rats. Other

The Tohoku journal … 2005 114 Zitierungen

Effects of N-acetylcysteine treatment on oxidative stress in acetic acid-induced experimental colitis in rats. Other

The Journal of … 2005 63 Zitierungen

Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells. Other

Journal of leukocyte … 2002

Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Other

Laboratory investigation; a … 2000 116 Zitierungen

Role of free radicals and poly(ADP-ribose) synthetase in intestinal tight junction permeability. Other

Molecular medicine (Cambridge, … 2000

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal … Other

Alimentary pharmacology & … 1999 57 Zitierungen

Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. Other

Gut 1996 297 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:: 600-1,200 mg/day in divided doses
hpyloriadjunct:: 600 mg twice daily alongside standard triple therapy
antioxidantsupport:: 600-900 mg/day

Obergrenze: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

In der Forschung untersuchte Dosierungen

Dosierung	Dauer	Wirkung	N
None	--	Mixed	--
N-acetylcysteine with thiopurine	16 weeks	Positive	--
None	--	Positive	--
150 mg/kg	4.3 weeks	Positive	--
400 IU/day	52 weeks	Mixed	--
None	--	Neutral	--
Various antioxidant compounds	--	Positive	--
None	--	Mixed	--

Beste Einnahmezeit: With or without food; divide doses throughout the day

Safety & Side Effects

Gemeldete Nebenwirkungen

⚠ Nausea and vomiting (most common, especially at higher doses)
⚠ Diarrhea
⚠ Unpleasant sulfur taste/odor
⚠ Headache

Bekannte Wechselwirkungen

● Nitroglycerin (NAC may enhance vasodilatory effects; risk of hypotension)
● Activated charcoal (may reduce NAC absorption)
● Anticoagulants (NAC may have mild antiplatelet effects)
● ACE inhibitors (additive hypotensive effect with nitroglycerin combination)

Tolerierbare Höchstaufnahmemenge: Generally well-tolerated up to 1,800 mg/day; higher doses used in clinical settings

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does N-Acetyl Cysteine (NAC) help with Inflammatory Bowel Disease (IBD) — General?

Based on 1 studies with 30 participants, there is preliminary evidence that needs more research that N-Acetyl Cysteine (NAC) may support Inflammatory Bowel Disease (IBD) — General management. Our evidence grade is D (Very Early Research).

How much N-Acetyl Cysteine (NAC) should I take for Inflammatory Bowel Disease (IBD) — General?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day in divided doses. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine (NAC)?

Reported side effects may include Nausea and vomiting (most common, especially at higher doses), Diarrhea, Unpleasant sulfur taste/odor, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine (NAC) and Inflammatory Bowel Disease (IBD) — General?

We rate the evidence as Grade D (Very Early Research). This rating is based on 1 peer-reviewed studies with 30 total participants. The overall direction of effect is positive.

Related Evidence

Andere Inhaltsstoffe für Inflammatory Bowel Disease (IBD) — General

Vitamin D B

N-Acetyl Cysteine (NAC) für andere Beschwerden

Helicobacter pylori Infection C

Kurzfazit

Pilot data only. Glutathione precursor may reduce oxidative stress in IBD. Requires larger clinical trials.

Evidence Strength30%

Low confidence

Studienübersicht

RCT (1)Meta (0)Other (0)

Alternativen vergleichen

Sehen Sie, wie andere Inhaltsstoffe bei dieser Beschwerde abschneiden.

Alle Inhaltsstoffe ansehen für Inflammatory Bowel Disease (IBD) — General

Mehr erfahren

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