Omega-3 Fatty Acids (EPA/DHA) لـ Crohn's Disease
CEPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
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C
الخلاصة
EPIC-1 and EPIC-2 large RCTs showed no benefit for maintaining Crohn's remission. Earlier smaller studies were more positive. Current consensus is neutral.
Key Study Findings
Other
Intestinal anti-inflammatory, histopathologic and anti-oxidative regulatory effects of total alkaloids extract from Linum usitatissimum L. …
Dose: 50, 100, and 200 mg/kg oral
مقابل: Dexamethasone 2.4 mg/kg; DNBS colitis model vs healthy
Outcome: Colonic inflammation markers (MPO, NO, MDA, CAT, GSH)
التأثير: None
None
المجتمع المدروس: DNBS-induced Crohn's disease BALB/c mouse model
Review
Gut microbiome-centric nutritional strategies in inflammatory bowel disease: Modulating dysbiosis for therapeutic benefit.
Dose: None
مقابل: None
Outcome: IBD microbiota modulation and immune regulation
التأثير: None
None
المجتمع المدروس: IBD patients (review of nutritional interventions)
Review
Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.
Dose: None
مقابل: None
Outcome: Athletic performance and nutritional optimization
التأثير: None
None
المجتمع المدروس: Vegan athletes (narrative review)
Other
Interaction between diet and genetics in patients with inflammatory bowel disease.
Dose: None
مقابل: None
Outcome: Diet-genetics interaction in IBD
التأثير: None
None
المجتمع المدروس: IBD patients (editorial commentary)
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
مقابل: None
Outcome: Colitis severity
التأثير: None
None
المجتمع المدروس: Crohn's disease patients
Observational Study
Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: …
Dose: 95%
مقابل: None
Outcome: inflammation markers
التأثير: None
None
المجتمع المدروس: None
Key Statistics
6
الدراسات
800
المشاركون
↔
Mixed
C
التقييم
Referenced Papers
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2025
4 اقتباسات
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3 اقتباسات
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12 اقتباسات
World journal of …
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Scientific reports
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56 اقتباسات
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2018
67 اقتباسات
International journal of …
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143 اقتباسات
Medical principles and …
2017
45 اقتباسات
Ugeskrift for laeger
2017
European journal of …
2016
79 اقتباسات
Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis.
Review
Current pharmaceutical design
2016
32 اقتباسات
Clinics in dermatology
2016
19 اقتباسات
The Cochrane database …
2014
88 اقتباسات
Alimentary pharmacology & …
2013
128 اقتباسات
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2012
145 اقتباسات
Dietary supplements for established atopic eczema.
Meta-Analysis
The Cochrane database …
2012
130 اقتباسات
World journal of …
2012
113 اقتباسات
Frontline gastroenterology
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20 اقتباسات
Pediatrics in review
2012
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Systematic Review
The American journal …
2011
946 اقتباسات
Inflammatory bowel diseases
2011
195 اقتباسات
Nutrition in clinical …
2011
1 اقتباسات
The Cochrane database …
2009
198 اقتباسات
Review article: the evidence base for interventions used to maintain remission in Crohn's disease.
Review
Alimentary pharmacology & …
2008
50 اقتباسات
The American journal …
2007
310 اقتباسات
Digestion
2007
15 اقتباسات
The Cochrane database …
2007
2 اقتباسات
Gastroenterology nursing : …
2006
24 اقتباسات
World journal of …
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80 اقتباسات
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Immunonutrition.
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Current opinion in …
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22 اقتباسات
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Journal of the …
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2016 اقتباسات
Enteral feeding.
Other
Current opinion in …
2002
1 اقتباسات
Enteral feeding.
Review
Current opinion in …
2002
Zeitschrift fur Gastroenterologie
1998
18 اقتباسات
Scandinavian journal of …
1996
195 اقتباسات
Arquivos de gastroenterologia
1996
Gut
1990
192 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 1,000-2,000 mg combined EPA/DHA per day
- ibdsupport:
- 2,000-4,000 mg/day combined EPA/DHA (higher EPA ratio may be more beneficial)
الحد الأعلى: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| 50, 100, and 200 mg/kg oral | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
| 95% | -- | Mixed | -- |
| None | -- | Mixed | 12194 |
| None | -- | Mixed | -- |
أفضل وقت للتناول: With meals containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Fishy aftertaste and burping
- ⚠ Mild gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Potential increased bleeding time at very high doses (>3 g/day)
- ⚠ May lower blood pressure slightly
التفاعلات المعروفة
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (fish oil may reduce cyclosporine nephrotoxicity but monitor levels)
الحد الأقصى المسموح به: 3,000 mg/day combined EPA/DHA (FDA GRAS limit)
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Crohn's Disease?
Based on 6 studies with 800 participants, there is limited but promising evidence that Omega-3 Fatty Acids (EPA/DHA) may support Crohn's Disease management. Our evidence grade is C (Some Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Crohn's Disease?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Mild gastrointestinal discomfort (nausea, diarrhea), Potential increased bleeding time at very high doses (>3 g/day), May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Crohn's Disease?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 800 total participants. The overall direction of effect is mixed.
Related Evidence
مكونات أخرى لـ Crohn's Disease
Omega-3 Fatty Acids (EPA/DHA) لحالات أخرى
إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.