**Figure 6.** Figure 1. Immunomodulation by natural product compounds involves an altered balance between subsets of diverse immune cell types. The corresponding pathogenic (pro-inﬂammatory) (Right panel) versus protective (anti-inﬂammatory/immunomodulatory) (Left panel) immune cell subsets are shown: Th1 vs. Th2, Th17 vs. Treg, M1 vs. M2, activating vs. tolerogenic DC, and antibodyproducing vs. regulatory B cells, respectively. (Abbreviations (Top to bottom)): Th = T helper cell; Treg = T regulatory cells; M1 = M1-type macrophage; M2 = M2-type macrophage; DC = dendritic cells (Right panel, activating DC; Left panel, tolerizing DC); B10 = B cells secreting IL-10 (a regulatory B cell subset); B cell = activated B cell for antibody production.

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Natural product compounds shift the balance between pathogenic pro-inflammatory immune cells (right panel) and protective anti-inflammatory/immunomodulatory cell subsets (left panel). This diagram illustrates how diverse natural products can rebalance immune cell populations in autoimmune disease.

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Figure 7

In vivo models of autoimmune diseases have demonstrated therapeutic efficacy of various natural compounds. This figure presents preclinical evidence from animal models of rheumatoid arthritis, multiple sclerosis, or inflammatory bowel disease treated with natural products.

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Figure 8

Clinical translation of natural anti-inflammatory products requires understanding of bioavailability and dose-response relationships. This figure discusses the therapeutic potential and limitations of natural product-based interventions for autoimmune conditions.

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Figure 6

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The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation.

International journal of molecular sciences (2022)

PMID: 36613560

DOI: 10.3390/ijms24010095

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![Figure 6: Natural product compounds shift the balance between pathogenic pro-inflammatory immune cells (right panel) and protective anti-inflammatory/immunomodulatory cell subsets (left panel). This diagram illustrates how diverse natural products can rebalance immune cell populations in autoimmune disease.](https://pdfs.citedhealth.com/figures/36613560/203.png)

> Source: Kamal D Moudgil et al. "The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Con." *International journal of molecular sciences*, 2022. PMID: [36613560](https://pubmed.ncbi.nlm.nih.gov/36613560/)

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  <img src="https://pdfs.citedhealth.com/figures/36613560/203.png" alt="Natural product compounds shift the balance between pathogenic pro-inflammatory immune cells (right panel) and protective anti-inflammatory/immunomodulatory cell subsets (left panel). This diagram illustrates how diverse natural products can rebalance immune cell populations in autoimmune disease." />
  <figcaption>Figure 6. Natural product compounds shift the balance between pathogenic pro-inflammatory immune cells (right panel) and protective anti-inflammatory/immunomodulatory cell subsets (left panel). This diagram illustrates how diverse natural products can rebalance immune cell populations in autoimmune disease.<br>  Source: Kamal D Moudgil et al. "The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Con." <em>International journal of molecular sciences</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36613560/">36613560</a></figcaption>
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