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Lactobacillus gasseri для Gastroesophageal Reflux Disease (GERD)

D

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

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D

Итог

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

Key Study Findings

Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None или: placebo Outcome: improvement in key IBS symptoms Эффект: None None

Популяция: patients with IBS from 32 RCTs evaluating 10 probiotic strains

In Vitro
Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in …
Dose: None или: H. pylori infection without lactobacilli Outcome: ADAM17, HBEGF, TGF-alpha expression Эффект: None None

Популяция: AGS gastric epithelial cells and mouse model

In Vitro
The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of …
Dose: 50 μg/ml или: None Outcome: Inflammatory markers Эффект: None None

Популяция: None

Other
Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter …
Dose: None или: None Outcome: Inflammatory markers Эффект: None None

Популяция: Cancer patients

In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None или: None Outcome: inflammation markers Эффект: None None

Популяция: Mice

Case-Control n=178
Oral and gastric microbiome in relation to gastric intestinal metaplasia.
Dose: None или: None Outcome: Oral/gastric microbiome associations with IM Эффект: None None

Популяция: Gastric intestinal metaplasia cases and matched controls

Key Statistics

3

Исследования

300

Участники

Positive

D

Оценка

Referenced Papers

International journal of … 2022 59 цитирований
Comparative immunology, microbiology … 2019 72 цитирований
Journal of clinical … 2012 37 цитирований
Probiotics and antimicrobial … 2010 9 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
1-10 billion CFU/day
gerdsupport:
1-5 billion CFU/day
hpylorisupport:
100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks

Верхний предел: Well-tolerated up to 10 billion CFU/day in clinical trials

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
None -- Positive --
50 μg/ml -- Mixed --
None -- Positive --
None -- Mixed --
None -- Neutral 178
None -- Positive --
None -- Positive --

Лучшее время приёма: Before meals or with meals; yogurt form taken with food

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Mild gas during initial use
  • Occasional loose stools
  • Rare abdominal discomfort
  • Very rare: bacteremia in immunocompromised individuals

Известные взаимодействия

  • Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
  • Proton pump inhibitors (altered gastric pH may affect colonization)
  • Immunosuppressants (theoretical risk in immunocompromised patients)

Допустимый верхний уровень потребления: Well-tolerated up to 10 billion CFU/day in clinical trials

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Lactobacillus gasseri help with Gastroesophageal Reflux Disease (GERD)?
Based on 3 studies with 300 participants, there is preliminary evidence that needs more research that Lactobacillus gasseri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is D (Very Early Research).
How much Lactobacillus gasseri should I take for Gastroesophageal Reflux Disease (GERD)?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus gasseri?
Reported side effects may include Mild gas during initial use, Occasional loose stools, Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus gasseri and Gastroesophageal Reflux Disease (GERD)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Gastroesophageal Reflux Disease (GERD)

Lactobacillus gasseri для других состояний

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.