Alpha-Galactosidase para Bloating and Intestinal Gas

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

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Conclusão

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

Key Study Findings

Review

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review.

Dose: None vs: None Outcome: None Efeito: None None

População: None

Randomized Controlled Trial Double-blind

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal …

Dose: 1200 G vs: placebo Outcome: every 30 min during 7 Efeito: None None

População: patients with ibs after three standardized

Other n=17

FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument.

Dose: None vs: no treatment Outcome: None Efeito: None None

População: fabry disease but are often nonspecific

Randomized Controlled Trial n=31 2.0 weeks Double-blind

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment.

Dose: 300 GALU or 150 GALU vs: Placebo (glucose) Outcome: GI symptom severity on VAS Efeito: None pP0.006

População: IBS patients (Rome III, H2 producers)

Randomized Controlled Trial n=125 4 weeks Double-blind

Does oral α-galactosidase relieve irritable bowel symptoms?

Dose: alpha-galactosidase 600 GalU per meal vs: placebo Outcome: overall IBS symptom relief Efeito: no significant difference vs placebo >0.05

População: IBS patients

Case Reports

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha …

Dose: 3.7nmol/mL/h vs: None Outcome: None Efeito: None None

População: patients

Key Statistics

Estudos

300

Participantes

↑

Positive

Nota

Referenced Papers

Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review. Review

International journal of … 2021 16 citações

FABry Disease Patient-Reported Outcome-GastroIntestinal (FABPRO-GI): A new Fabry disease-specific gastrointestinal outcomes instrument. Other

Quality of life … 2021 14 citações

A randomized double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome … RCT

Neurogastroenterology and motility 2021 4 citações

Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. RCT

The American journal … 2018 49 citações

Does oral α-galactosidase relieve irritable bowel symptoms? RCT

Scandinavian journal of … 2016 17 citações

A family with various symptomatology suggestive of Anderson-Fabry disease and a genetic polymorphism of alpha galactosidase A gene. Case Report

Clinical biochemistry 2015 18 citações

Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial. RCT

BMC gastroenterology 2013 12 citações

The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. RCT

Digestive diseases and … 2007 45 citações

Gastrointestinal manifestations of Fabry disease: clinical response to enzyme replacement therapy. Other

Molecular genetics and … 2005 84 citações

Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. RCT

The Journal of … 1994

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods
standardbeanodose:: 300 GalU (2-3 tablets) with first bite of problem food

Limite superior: No established upper limit; adjust per meal as needed

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
None	--	Mixed	--
1200 G	--	Neutral	--
None	--	Positive	17
300 GALU or 150 GALU	2.0 weeks	Positive	31
alpha-galactosidase 600 GalU per meal	4 weeks	Neutral	125
3.7nmol/mL/h	--	Mixed	--
None	2 weeks	Positive	--
300 or 1200 GalU	--	Positive	8

Melhor horário: With the first bite of gas-producing food

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Generally very well-tolerated
⚠ Rare allergic reactions to mold-derived enzyme (Aspergillus source)
⚠ May cause mild GI discomfort in rare cases

Interações Conhecidas

● Acarbose (alpha-galactosidase may counteract the blood sugar-lowering mechanism of acarbose; contraindicated for concurrent use)
● Miglitol (similar mechanism conflict as acarbose)

Ingestão máxima tolerável: No established upper limit; adjust per meal as needed

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Alpha-Galactosidase help with Bloating and Intestinal Gas?

Based on 4 studies with 300 participants, there is moderate evidence from clinical studies that Alpha-Galactosidase may support Bloating and Intestinal Gas management. Our evidence grade is B (Good Evidence).

How much Alpha-Galactosidase should I take for Bloating and Intestinal Gas?

Studies have used various dosages. A commonly studied range is 150-300 GalU (alpha-galactosidase units) per serving of gas-producing foods. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Galactosidase?

Reported side effects may include Generally very well-tolerated, Rare allergic reactions to mold-derived enzyme (Aspergillus source), May cause mild GI discomfort in rare cases. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Galactosidase and Bloating and Intestinal Gas?

We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Bloating and Intestinal Gas

Pancreatic Enzymes (Pancrelipase) A Ginger B Lactobacillus reuteri B Medium-Chain Triglycerides (MCT Oil) C

Alpha-Galactosidase para outras condições

Irritable Bowel Syndrome (IBS) D

Veredito Rápido

Reduces gas symptoms from high-fiber foods containing raffinose/stachyose by 50-70%. Beano (alpha-galactosidase 300 GalU) is the most studied formulation.

Evidence Strength72%

High confidence

Detalhamento dos Estudos

RCT (6)Meta (0)Other (0)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Bloating and Intestinal Gas

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.