Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut et al.

Other Nature medicine 2007 774 citations

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Study Design

Study Type: Other
Population: None

Intervention: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. None
Comparator: None
Primary Outcome: Lactobacillus acidophilus modulates intestinal pain and induces opioid and canna
Effect Direction: Mixed
Risk of Bias: Moderate

Abstract

Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.

TL;DR

It is found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut—similar to the effects of morphine.

Used In Evidence Reviews

B Lactobacillus acidophilus for Irritable Bowel Syndrome (IBS)

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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