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Fermentation process optimization parameters for probiotic-herbal bioactive production, including temperature, pH, substrate ratios, and incubation time. Process engineering considerations for maximizing therapeutic compound yield are reviewed.

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![Figure 17: Fermentation process optimization parameters for probiotic-herbal bioactive production, including temperature, pH, substrate ratios, and incubation time. Process engineering considerations for maximizing therapeutic compound yield are reviewed.]()

> Source: Yue Fan et al. "Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insigh." *International journal of molecular sciences*, 2025. PMID: [40564947](https://pubmed.ncbi.nlm.nih.gov/40564947/)
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  <img src="" alt="Fermentation process optimization parameters for probiotic-herbal bioactive production, including temperature, pH, substrate ratios, and incubation time. Process engineering considerations for maximizing therapeutic compound yield are reviewed." />
  <figcaption>Figure 17. Fermentation process optimization parameters for probiotic-herbal bioactive production, including temperature, pH, substrate ratios, and incubation time. Process engineering considerations for maximizing therapeutic compound yield are reviewed.<br>  Source: Yue Fan et al. "Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insigh." <em>International journal of molecular sciences</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40564947/">40564947</a></figcaption>
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