What is the recommended dosage for Berberine?

General: 500-1,500 mg/day in divided doses; Sibo Protocol: 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol); Gi Antimicrobial: 500 mg twice daily

What are the side effects of Berberine?

Potential side effects include: GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common, May cause uterine contractions (contraindicated in pregnancy), Headache, Skin rash (rare).

What is berberine and how does it work for gut health?

Berberine is a bioactive alkaloid found in plants like goldenseal, barberry, and Oregon grape. Research suggests it may support gut health by modulating the gut microbiome, enhancing intestinal barrier function, and exerting antimicrobial effects against harmful bacteria. It also activates AMPK, an enzyme involved in metabolic regulation that may influence gut inflammation.

What is the recommended dosage of berberine?

Most clinical studies use berberine at 900-1500 mg per day, divided into 2-3 doses taken with meals. A common protocol is 500 mg three times daily. Splitting the dose helps maintain stable blood levels and may reduce gastrointestinal side effects, which are more common at higher single doses.

Are there side effects or interactions with berberine?

The most common side effects of berberine are gastrointestinal, including diarrhea, constipation, flatulence, and abdominal pain, particularly at higher doses. Berberine has significant drug interactions — it can affect the metabolism of medications processed by CYP enzymes, including statins, blood thinners, and diabetes medications. It should not be used during pregnancy, and medical supervision is strongly recommended.

Berberine
Berberine

herb

別名: Berberine HCl, Berberine Hydrochloride, Goldenseal extract, Oregon Grape extract

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About

Berberine is an isoquinoline alkaloid found in several plants including goldenseal, Oregon grape, and barberry. It activates the AMPK pathway in enterocytes and exhibits direct antimicrobial activity against various enteric pathogens. Research suggests berberine may help modulate gut microbiome composition, including supporting the growth of Akkermansia muciniphila, a keystone species for gut barrier health. It is increasingly studied as part of herbal antimicrobial protocols for SIBO.

How It Works

Activates AMPK pathway in enterocytes modulating cellular energy metabolism; directly antimicrobial against enteric pathogens (E. coli, Staphylococcus, Candida); modulates gut microbiome composition increasing Akkermansia muciniphila; enhances intestinal barrier via tight junction protein upregulation.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Acute Diarrhea	C	4	400	詳細を見る →
Small Intestinal Bacterial Overgrowth (SIBO)	C	2	180	詳細を見る →
Gut Dysbiosis	D	2	100	詳細を見る →

Side Effects

GI side effects (diarrhea, constipation, flatulence, abdominal pain) — most common
May cause uterine contractions (contraindicated in pregnancy)
Headache
Skin rash (rare)

Drug & Supplement Interactions

Diabetes medications (berberine significantly lowers blood sugar; risk of hypoglycemia)
Cyclosporine (berberine inhibits CYP3A4, increasing cyclosporine levels)
Anticoagulants (may have additive blood-thinning effects)
Metformin (additive glucose-lowering effect; monitor closely)
Macrolide antibiotics (berberine inhibits CYP3A4)

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Related Ingredients

Curcumin Peppermint Oil Ginger Slippery Elm Deglycyrrhizinated Licorice (DGL)

基本情報

用量: General: 500-1,500 mg/day in divided doses; Sibo_Protocol: 500 mg two to three times daily for 4 weeks (as part of herbal antimicrobial protocol); Gi_Antimicrobial: 500 mg twice daily
剤形: capsule tablet liquid extract
天然の供給源: Goldenseal (Hydrastis canadensis), Oregon grape (Mahonia aquifolium), Barberry (Berberis vulgaris), Coptis (Coptis chinensis), Phellodendron (Amur cork tree)
上限量: Generally well-tolerated up to 1,500 mg/day in divided doses
推奨摂取タイミング: With meals; divide doses throughout the day (do not take full daily dose at once)

エビデンスの要約

Acute Diarrhea C

Small Intestinal Bacterial Overgrowth (SIBO) C

Gut Dysbiosis D

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。