Bovine Colostrum ： Increased Intestinal Permeability (Leaky Gut)
BMay help reduce exercise-induced and NSAID-induced increases in intestinal permeability. Colostrum (20-60 g/day) truncated permeability increase by ~80% in athletes.
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B
結論
May help reduce exercise-induced and NSAID-induced increases in intestinal permeability. Colostrum (20-60 g/day) truncated permeability increase by ~80% in athletes.
Key Study Findings
Controlled Clinical Trial
n=18
4 weeks
The effect of adding colostrum or sodium butyrate to the diet on the intestinal barrier …
Dose: None
vs: control (no additive)
Outcome: intestinal barrier function and growth performance
効果: None
p<0.001
対象集団: weaned DanBred Hybrid piglets aged 28 days
Review
Clinical Applications of Bovine Colostrum in GastrointestinaI Disorders: Mechanisms, Evidence, and Therapeutic Potential.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Randomized Controlled Trial
n=65
10 weeks
Evaluation of bovine colostrum replacer supplementation to improve weaning transition in Holstein dairy calves.
Dose: Bovine colostrum replacer during weaning
vs: No colostrum supplementation
Outcome: Intestinal permeability and weight gain
効果: None
None
対象集団: Holstein dairy calves during weaning
Meta-Analysis
Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized …
Dose: None
vs: Control
Outcome: Inflammatory markers
効果: MD: -0.01
None
対象集団: None
In Vitro
Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control.
Dose: None
vs: None
Outcome: Cytokine production (IL-6/IL-10 axis)
効果: None
p < 0.05
対象集団: In vitro (Caco-2/THP-1 co-culture model)
In Vitro
n=13
5.0 weeks
Intestine Health and Barrier Function in Fattening Rabbits Fed Bovine Colostrum.
Dose: 2.5%
vs: control
Outcome: inflammation markers
効果: None
p < 0.001
対象集団: Bovine
Key Statistics
4
研究数
300
参加者数
↑
Positive
B
グレード
Referenced Papers
PloS one
2026
International journal of …
2025
Digestive diseases and …
2024
4 件の引用
Journal of dairy …
2024
1 件の引用
Veterinary sciences
2023
9 件の引用
Veterinary sciences
2023
7 件の引用
A Systematic Review of the Influence of Bovine Colostrum Supplementation on Leaky Gut Syndrome in Athletes: Diagnostic Biomarkers and Future …
Systematic Review
Nutrients
2022
11 件の引用
Biomedicines
2022
7 件の引用
Nutrients
2021
26 件の引用
Medicine
2021
2 件の引用
Frontiers in immunology
2020
24 件の引用
Medicina (Kaunas, Lithuania)
2020
18 件の引用
European journal of …
2019
42 件の引用
Nutrition (Burbank, Los …
2019
37 件の引用
European journal of …
2017
93 件の引用
Nutrients
2017
49 件の引用
The American journal …
2016
75 件の引用
American journal of …
2016
15 件の引用
American journal of …
2015
85 件の引用
Journal of animal …
2014
15 件の引用
American journal of …
2011
161 件の引用
Nutrients
2009
30 件の引用
Journal of medicinal …
2009
25 件の引用
Clinical nutrition (Edinburgh, …
2005
43 件の引用
Asia Pacific journal …
2005
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 10-20 g/day
- travelersdiarrhea:
- Hyperimmune colostrum: 400-3,600 mg/day (anti-ETEC formulation)
- exercisegutprotection:
- 20 g/day starting 14 days before intense exercise
- intestinalpermeability:
- 20-60 g/day for gut barrier support
上限量： No established upper limit; most studies use 10-60 g/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | 4 weeks | Positive | 18 |
| None | -- | Mixed | -- |
| Bovine colostrum replacer during weaning | 10 weeks | Positive | 65 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 2.5% | 5.0 weeks | Mixed | 13 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： On an empty stomach (30 minutes before meals) for gut barrier support
Safety & Side Effects
報告されている副作用
- ⚠ Mild GI discomfort (bloating, nausea) during initial use
- ⚠ Not suitable for individuals with cow's milk protein allergy
- ⚠ Lactose content may affect lactose-intolerant individuals
- ⚠ Potential concern about growth factor (IGF-1) content in cancer survivors (theoretical)
既知の相互作用
- ● Immunosuppressants (colostrum immunoglobulins may theoretically interfere; clinical significance unclear)
- ● No significant adverse drug interactions established
耐容上限摂取量： No established upper limit; most studies use 10-60 g/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Bovine Colostrum help with Increased Intestinal Permeability (Leaky Gut)?
Based on 4 studies with 300 participants, there is moderate evidence from clinical studies that Bovine Colostrum may support Increased Intestinal Permeability (Leaky Gut) management. Our evidence grade is B (Good Evidence).
How much Bovine Colostrum should I take for Increased Intestinal Permeability (Leaky Gut)?
Studies have used various dosages. A commonly studied range is 10-20 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bovine Colostrum?
Reported side effects may include Mild GI discomfort (bloating, nausea) during initial use, Not suitable for individuals with cow's milk protein allergy, Lactose content may affect lactose-intolerant individuals, Potential concern about growth factor (IGF-1) content in cancer survivors (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bovine Colostrum and Increased Intestinal Permeability (Leaky Gut)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Increased Intestinal Permeability (Leaky Gut)
Bovine Colostrum 他の症状・状態について
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