Lactobacillus gasseri per Gastroesophageal Reflux Disease (GERD)

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

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In sintesi

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms Effetto: None None

Popolazione: patients with IBS from 32 RCTs evaluating 10 probiotic strains

In Vitro

Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in …

Dose: None vs: H. pylori infection without lactobacilli Outcome: ADAM17, HBEGF, TGF-alpha expression Effetto: None None

Popolazione: AGS gastric epithelial cells and mouse model

In Vitro

The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of …

Dose: 50 μg/ml vs: None Outcome: Inflammatory markers Effetto: None None

Popolazione: None

Other

Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter …

Dose: None vs: None Outcome: Inflammatory markers Effetto: None None

Popolazione: Cancer patients

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None vs: None Outcome: inflammation markers Effetto: None None

Popolazione: Mice

Case-Control n=178

Oral and gastric microbiome in relation to gastric intestinal metaplasia.

Dose: None vs: None Outcome: Oral/gastric microbiome associations with IM Effetto: None None

Popolazione: Gastric intestinal metaplasia cases and matched controls

Key Statistics

Studi

300

Partecipanti

↑

Positive

Grado

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells. Other

International journal of … 2025

The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of Helicobacter pylori in gastric epithelial … Other

Microbial pathogenesis 2024 8 citazioni

Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter pylori Infection. Other

Helicobacter 2024 5 citazioni

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 citazioni

Oral and gastric microbiome in relation to gastric intestinal metaplasia. Other

International journal of … 2022 59 citazioni

Anti-Helicobacter pylori activity of potential probiotic Lactiplantibacillus pentosus SLC13. Other

BMC microbiology 2022 28 citazioni

Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori infection in C57BL/6 mice. Other

Food & function 2022 19 citazioni

Effects of a Potential Probiotic Strain Lactobacillus gasseri ATCC 33323 on Helicobacter pylori-Induced Inflammatory Response and Gene Expression in Coinfected … Other

Probiotics and antimicrobial … 2021 30 citazioni

Are probiotics useful for therapy of Helicobacter pylori diseases? Review

Comparative immunology, microbiology … 2019 72 citazioni

Probiotic L. gasseri strain (LG21) for the upper gastrointestinal tract acting through improvement of indigenous microbiota. Review

BMJ open gastroenterology 2019 14 citazioni

The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study. RCT

Digestion 2017 67 citazioni

Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Other

Gastroenterology research and … 2016 38 citazioni

Mouse Models for Assessing the Protective Efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis Infection Associated with the Development of … Other

Helicobacter 2015 26 citazioni

The effect of probiotics supplementation on Helicobacter pylori eradication rates and side effects during eradication therapy: a meta-analysis. Meta-Analysis

PloS one 2014 171 citazioni

Probiotic and technological properties of Lactobacillus spp. strains from the human stomach in the search for potential candidates against gastric … Other

Frontiers in microbiology 2014 78 citazioni

Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health. Review

FEMS microbiology reviews 2013 196 citazioni

Antagonistic activities of lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. Other

Journal of food … 2012 56 citazioni

Probiotic mechanism of Lactobacillus gasseri OLL2716 strain against Helicobacter pylori. Other

Journal of clinical … 2012 37 citazioni

Oral administration of lactobacilli from human intestinal tract protects mice against influenza virus infection. Other

Letters in applied … 2010 126 citazioni

Fermentation metabolites from Lactobacillus gasseri and Propionibacterium freudenreichii exert bacteriocidal effects in mice. Other

Journal of medicinal … 2010 19 citazioni

Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori. Other

Probiotics and antimicrobial … 2010 9 citazioni

Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection. RCT

Helicobacter 2009 48 citazioni

Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure. Other

Cellular microbiology 2006 50 citazioni

Detection of Lactobacillus gasseri OLL2716 strain administered with yogurt drink in gastric mucus layer in humans. Other

Letters in applied … 2006 26 citazioni

Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. Other

Journal of gastroenterology … 2003 77 citazioni

Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Other

The Journal of … 2001 309 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 1-10 billion CFU/day
gerdsupport:: 1-5 billion CFU/day
hpylorisupport:: 100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks

Limite massimo: Well-tolerated up to 10 billion CFU/day in clinical trials

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
None	--	Positive	--
50 μg/ml	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Neutral	178
None	--	Positive	--
None	--	Positive	--

Momento migliore per l'assunzione: Before meals or with meals; yogurt form taken with food

Safety & Side Effects

Effetti collaterali segnalati

⚠ Mild gas during initial use
⚠ Occasional loose stools
⚠ Rare abdominal discomfort
⚠ Very rare: bacteremia in immunocompromised individuals

Interazioni note

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Proton pump inhibitors (altered gastric pH may affect colonization)
● Immunosuppressants (theoretical risk in immunocompromised patients)

Livello di assunzione massimo tollerabile: Well-tolerated up to 10 billion CFU/day in clinical trials

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Lactobacillus gasseri help with Gastroesophageal Reflux Disease (GERD)?

Based on 3 studies with 300 participants, there is preliminary evidence that needs more research that Lactobacillus gasseri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is D (Very Early Research).

How much Lactobacillus gasseri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus gasseri?

Reported side effects may include Mild gas during initial use, Occasional loose stools, Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus gasseri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Gastroesophageal Reflux Disease (GERD)

Lactobacillus reuteri C Ginger D Slippery Elm D

Lactobacillus gasseri per altre condizioni

Helicobacter pylori Infection B

Verdetto rapido

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

Evidence Strength30%

Low confidence

Analisi degli studi

RCT (2)Meta (1)Other (0)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Gastroesophageal Reflux Disease (GERD)

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.