What is the recommended dosage for Bifidobacterium lactis?

General: 1-10 billion CFU/day; Immune Support: 5-10 billion CFU/day; Constipation Support: 17.2 billion CFU/day (HN019 strain, optimal dose)

What are the side effects of Bifidobacterium lactis?

Potential side effects include: Mild gas and bloating during initial use, Occasional abdominal discomfort, Rare loose stools, Very rare: bacteremia in immunocompromised individuals.

What is Bifidobacterium lactis and how does it work for gut health?

Bifidobacterium lactis (also classified as B. animalis subsp. lactis) is one of the most widely studied probiotic strains. It has been shown to improve bowel regularity, reduce bloating, and support immune function. Key strains like BB-12 and HN019 have extensive clinical evidence for improving gut transit time and supporting digestive comfort.

What is the recommended dosage of Bifidobacterium lactis?

Clinical dosages typically range from 1 billion to 25 billion CFU per day. The strain BB-12 has been studied at doses of 1-10 billion CFU, while HN019 has shown benefits at 1.8-17.2 billion CFU daily. Higher doses have been associated with greater improvements in gut transit time in some studies.

Are there side effects or interactions with Bifidobacterium lactis?

Bifidobacterium lactis has one of the strongest safety records among probiotic strains, with extensive use in dairy products and supplements worldwide. Side effects are uncommon and generally mild, including temporary gas or bloating. It has no known significant drug interactions but, as with all probiotics, immunocompromised individuals should seek medical advice first.

Bifidobacterium lactis

probiotic_strain

Also known as: B. lactis, Bifidobacterium animalis subsp. lactis, HN019, BB-12, Bi-07

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About

Bifidobacterium lactis is a well-studied probiotic species that supports digestive regularity and immune function. Research suggests it may help modulate intestinal immune responses via natural killer cell activation and support colonic transit time. The HN019 strain has been particularly studied for its dose-dependent effects on whole gut transit time, showing up to 31% reduction at higher doses.

How It Works

Modulates intestinal immune response via NK cell activation and enhanced phagocytic activity; improves colonic transit time in a dose-dependent manner; produces acetate that strengthens gut barrier integrity and lowers colonic pH; enhances mucus layer thickness.

Evidence For Conditions

Condition	Grade	Studies	Participants
Chronic Constipation	B	4	600	View →

Side Effects

Mild gas and bloating during initial use
Occasional abdominal discomfort
Rare loose stools
Very rare: bacteremia in immunocompromised individuals

Drug & Supplement Interactions

Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
Immunosuppressants (use with caution in immunocompromised patients)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bacillus coagulans Bifidobacterium bifidum Bifidobacterium breve Bifidobacterium longum Lactobacillus acidophilus

Quick Facts

Dosage: General: 1-10 billion CFU/day; Immune_Support: 5-10 billion CFU/day; Constipation_Support: 17.2 billion CFU/day (HN019 strain, optimal dose)
Forms: capsule powder sachet yogurt
Natural Sources: Fermented dairy products, Yogurt, Kefir, Breast milk (infant colonization)
Upper Limit: Well-tolerated up to 17.2 billion CFU/day in clinical trials
Best Time: With or without food; morning dosing may be optimal for transit effects

Evidence Summary

Chronic Constipation B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.