Lactobacillus gasseri untuk Helicobacter pylori Infection

Three RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.

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Kesimpulan

Three RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.

Key Study Findings

In Vitro

Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in …

Dose: None vs: H. pylori infection without lactobacilli Outcome: ADAM17, HBEGF, TGF-alpha expression Efek: None None

Populasi: AGS gastric epithelial cells and mouse model

In Vitro

Lactobacillus gasseri Suppresses the Helicobacter pylori-Induced Hummingbird Phenotype by Inhibiting CagA Phosphorylation and SHP-2 Interaction.

Dose: None vs: CagA-expressing AGS cells without L. gasseri Outcome: Suppression of CagA phosphorylation (hummingbird) Efek: None None

Populasi: Human gastric AGS cell line with H. pylori CagA

In Vitro

The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of …

Dose: 50 μg/ml vs: None Outcome: Inflammatory markers Efek: None None

Populasi: None

Other

Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter …

Dose: None vs: None Outcome: Inflammatory markers Efek: None None

Populasi: Cancer patients

Other

Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori …

Dose: None vs: None Outcome: H. pylori abundance reduction Efek: None None

Populasi: H. pylori-infected C57BL/6 mice

Case-Control n=178

Oral and gastric microbiome in relation to gastric intestinal metaplasia.

Dose: None vs: None Outcome: Oral/gastric microbiome associations with IM Efek: None None

Populasi: Gastric intestinal metaplasia cases and matched controls

Key Statistics

Studi

350

Peserta

↑

Positive

Peringkat

Referenced Papers

Lactobacillus gasseri Suppresses the Helicobacter pylori-Induced Hummingbird Phenotype by Inhibiting CagA Phosphorylation and SHP-2 Interaction. Other

International journal of … 2025 4 sitasi

Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells. Other

International journal of … 2025

The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of Helicobacter pylori in gastric epithelial … Other

Microbial pathogenesis 2024 8 sitasi

Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter pylori Infection. Other

Helicobacter 2024 5 sitasi

Oral and gastric microbiome in relation to gastric intestinal metaplasia. Other

International journal of … 2022 59 sitasi

Anti-Helicobacter pylori activity of potential probiotic Lactiplantibacillus pentosus SLC13. Other

BMC microbiology 2022 28 sitasi

Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori infection in C57BL/6 mice. Other

Food & function 2022 19 sitasi

Effects of a Potential Probiotic Strain Lactobacillus gasseri ATCC 33323 on Helicobacter pylori-Induced Inflammatory Response and Gene Expression in Coinfected … Other

Probiotics and antimicrobial … 2021 30 sitasi

Are probiotics useful for therapy of Helicobacter pylori diseases? Review

Comparative immunology, microbiology … 2019 72 sitasi

Lactobacillus gasseri Suppresses the Production of Proinflammatory Cytokines in Helicobacter pylori-Infected Macrophages by Inhibiting the Expression of ADAM17. Other

Frontiers in immunology 2019 61 sitasi

Role of Sortase A in Lactobacillus gasseri Kx110A1 Adhesion to Gastric Epithelial Cells and Competitive Exclusion of Helicobacter pylori. Other

Frontiers in microbiology 2019 31 sitasi

Probiotic L. gasseri strain (LG21) for the upper gastrointestinal tract acting through improvement of indigenous microbiota. Review

BMJ open gastroenterology 2019 14 sitasi

The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study. RCT

Digestion 2017 67 sitasi

Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Other

Gastroenterology research and … 2016 38 sitasi

Mouse Models for Assessing the Protective Efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis Infection Associated with the Development of … Other

Helicobacter 2015 26 sitasi

The effect of probiotics supplementation on Helicobacter pylori eradication rates and side effects during eradication therapy: a meta-analysis. Meta-Analysis

PloS one 2014 171 sitasi

Probiotic and technological properties of Lactobacillus spp. strains from the human stomach in the search for potential candidates against gastric … Other

Frontiers in microbiology 2014 78 sitasi

Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health. Review

FEMS microbiology reviews 2013 196 sitasi

Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. RCT

Journal of gastroenterology … 2012 76 sitasi

Antagonistic activities of lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. Other

Journal of food … 2012 56 sitasi

Probiotic mechanism of Lactobacillus gasseri OLL2716 strain against Helicobacter pylori. Other

Journal of clinical … 2012 37 sitasi

In vitro screening of lactobacilli with antagonistic activity against Helicobacter pylori from traditionally fermented foods. Other

Journal of dairy … 2010 43 sitasi

Fermentation metabolites from Lactobacillus gasseri and Propionibacterium freudenreichii exert bacteriocidal effects in mice. Other

Journal of medicinal … 2010 19 sitasi

Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori. Other

Probiotics and antimicrobial … 2010 9 sitasi

Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection. RCT

Helicobacter 2009 48 sitasi

Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure. Other

Cellular microbiology 2006 50 sitasi

Suppression of Helicobacter pylori-induced interleukin-8 production in vitro and within the gastric mucosa by a live Lactobacillus strain. Other

Journal of gastroenterology … 2006 41 sitasi

Detection of Lactobacillus gasseri OLL2716 strain administered with yogurt drink in gastric mucus layer in humans. Other

Letters in applied … 2006 26 sitasi

Yogurt containing Lactobacillus gasseri OLL2716 exerts gastroprotective action against [correction of agaisnt] acute gastric lesion and antral ulcer in rats. Other

Journal of pharmacological … 2004 58 sitasi

Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. Other

Journal of gastroenterology … 2003 77 sitasi

Effects of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in children. Other

The Journal of … 2002 31 sitasi

Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Other

The Journal of … 2001 309 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 1-10 billion CFU/day
gerdsupport:: 1-5 billion CFU/day
hpylorisupport:: 100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks

Batas atas: Well-tolerated up to 10 billion CFU/day in clinical trials

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	--
None	--	Positive	--
50 μg/ml	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Neutral	178
None	--	Positive	--
1 g	--	Positive	--

Waktu terbaik diminum: Before meals or with meals; yogurt form taken with food

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Mild gas during initial use
⚠ Occasional loose stools
⚠ Rare abdominal discomfort
⚠ Very rare: bacteremia in immunocompromised individuals

Interaksi yang Diketahui

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Proton pump inhibitors (altered gastric pH may affect colonization)
● Immunosuppressants (theoretical risk in immunocompromised patients)

Asupan atas yang dapat ditoleransi: Well-tolerated up to 10 billion CFU/day in clinical trials

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Frequently Asked Questions

Does Lactobacillus gasseri help with Helicobacter pylori Infection?

Based on 3 studies with 350 participants, there is moderate evidence from clinical studies that Lactobacillus gasseri may support Helicobacter pylori Infection management. Our evidence grade is B (Good Evidence).

How much Lactobacillus gasseri should I take for Helicobacter pylori Infection?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus gasseri?

Reported side effects may include Mild gas during initial use, Occasional loose stools, Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus gasseri and Helicobacter pylori Infection?

We rate the evidence as Grade B (Good Evidence). This rating is based on 3 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Helicobacter pylori Infection

N-Acetyl Cysteine (NAC) C

Lactobacillus gasseri untuk kondisi lain

Gastroesophageal Reflux Disease (GERD) D

Kesimpulan Singkat

Three RCTs show L. gasseri LG21 suppresses H. pylori load and improves eradication rates when combined with standard triple therapy. Also improves GERD symptoms.

Evidence Strength72%

High confidence

Rincian Studi

RCT (3)Meta (1)Other (0)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Helicobacter pylori Infection

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.