Lactobacillus gasseri para Gastroesophageal Reflux Disease (GERD)

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

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Conclusión

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

Key Study Findings

Meta-Analysis

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.

Dose: None vs: placebo Outcome: improvement in key IBS symptoms Efecto: None None

Población: patients with IBS from 32 RCTs evaluating 10 probiotic strains

In Vitro

Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in …

Dose: None vs: H. pylori infection without lactobacilli Outcome: ADAM17, HBEGF, TGF-alpha expression Efecto: None None

Población: AGS gastric epithelial cells and mouse model

In Vitro

The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of …

Dose: 50 μg/ml vs: None Outcome: Inflammatory markers Efecto: None None

Población: None

Other

Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter …

Dose: None vs: None Outcome: Inflammatory markers Efecto: None None

Población: Cancer patients

In Vitro

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …

Dose: None vs: None Outcome: inflammation markers Efecto: None None

Población: Mice

Case-Control n=178

Oral and gastric microbiome in relation to gastric intestinal metaplasia.

Dose: None vs: None Outcome: Oral/gastric microbiome associations with IM Efecto: None None

Población: Gastric intestinal metaplasia cases and matched controls

Key Statistics

Estudios

300

Participantes

↑

Positive

Calificación

Referenced Papers

Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome. Review

Journal of clinical … 2026

Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells. Other

International journal of … 2025

The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of Helicobacter pylori in gastric epithelial … Other

Microbial pathogenesis 2024 8 citas

Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter pylori Infection. Other

Helicobacter 2024 5 citas

Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability in a Chronic-Restraint Stress Model. Other

International journal of … 2023 9 citas

Oral and gastric microbiome in relation to gastric intestinal metaplasia. Other

International journal of … 2022 59 citas

Anti-Helicobacter pylori activity of potential probiotic Lactiplantibacillus pentosus SLC13. Other

BMC microbiology 2022 28 citas

Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori infection in C57BL/6 mice. Other

Food & function 2022 19 citas

Effects of a Potential Probiotic Strain Lactobacillus gasseri ATCC 33323 on Helicobacter pylori-Induced Inflammatory Response and Gene Expression in Coinfected … Other

Probiotics and antimicrobial … 2021 30 citas

Are probiotics useful for therapy of Helicobacter pylori diseases? Review

Comparative immunology, microbiology … 2019 72 citas

Probiotic L. gasseri strain (LG21) for the upper gastrointestinal tract acting through improvement of indigenous microbiota. Review

BMJ open gastroenterology 2019 14 citas

The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study. RCT

Digestion 2017 67 citas

Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial. Other

Gastroenterology research and … 2016 38 citas

Mouse Models for Assessing the Protective Efficacy of Lactobacillus gasseri SBT2055 against Helicobacter suis Infection Associated with the Development of … Other

Helicobacter 2015 26 citas

The effect of probiotics supplementation on Helicobacter pylori eradication rates and side effects during eradication therapy: a meta-analysis. Meta-Analysis

PloS one 2014 171 citas

Probiotic and technological properties of Lactobacillus spp. strains from the human stomach in the search for potential candidates against gastric … Other

Frontiers in microbiology 2014 78 citas

Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health. Review

FEMS microbiology reviews 2013 196 citas

Antagonistic activities of lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. Other

Journal of food … 2012 56 citas

Probiotic mechanism of Lactobacillus gasseri OLL2716 strain against Helicobacter pylori. Other

Journal of clinical … 2012 37 citas

Oral administration of lactobacilli from human intestinal tract protects mice against influenza virus infection. Other

Letters in applied … 2010 126 citas

Fermentation metabolites from Lactobacillus gasseri and Propionibacterium freudenreichii exert bacteriocidal effects in mice. Other

Journal of medicinal … 2010 19 citas

Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori. Other

Probiotics and antimicrobial … 2010 9 citas

Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection. RCT

Helicobacter 2009 48 citas

Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure. Other

Cellular microbiology 2006 50 citas

Detection of Lactobacillus gasseri OLL2716 strain administered with yogurt drink in gastric mucus layer in humans. Other

Letters in applied … 2006 26 citas

Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. Other

Journal of gastroenterology … 2003 77 citas

Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Other

The Journal of … 2001 309 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 1-10 billion CFU/day
gerdsupport:: 1-5 billion CFU/day
hpylorisupport:: 100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks

Límite superior: Well-tolerated up to 10 billion CFU/day in clinical trials

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Positive	--
None	--	Positive	--
50 μg/ml	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Neutral	178
None	--	Positive	--
None	--	Positive	--

Mejor momento para tomar: Before meals or with meals; yogurt form taken with food

Safety & Side Effects

Efectos secundarios reportados

⚠ Mild gas during initial use
⚠ Occasional loose stools
⚠ Rare abdominal discomfort
⚠ Very rare: bacteremia in immunocompromised individuals

Interacciones conocidas

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Proton pump inhibitors (altered gastric pH may affect colonization)
● Immunosuppressants (theoretical risk in immunocompromised patients)

Ingesta máxima tolerable: Well-tolerated up to 10 billion CFU/day in clinical trials

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Lactobacillus gasseri help with Gastroesophageal Reflux Disease (GERD)?

Based on 3 studies with 300 participants, there is preliminary evidence that needs more research that Lactobacillus gasseri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is D (Very Early Research).

How much Lactobacillus gasseri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus gasseri?

Reported side effects may include Mild gas during initial use, Occasional loose stools, Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus gasseri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Gastroesophageal Reflux Disease (GERD)

Lactobacillus reuteri C Ginger D Slippery Elm D

Lactobacillus gasseri para otras condiciones

Helicobacter pylori Infection B

Veredicto rápido

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

Evidence Strength30%

Low confidence

Desglose de estudios

RCT (2)Meta (1)Other (0)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Gastroesophageal Reflux Disease (GERD)

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.