The interaction between obesity and visceral hypersensitivity.

Wu Yanping, Xuefen Gao, Yizun Cheng, Mi Liu, Siyu Liao et al.

Review Journal of gastroenterology and hepatology 2023 16 atıf

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Study Design

Çalışma Türü: Review
Popülasyon: None

Müdahale: The interaction between obesity and visceral hypersensitivity. None
Karşılaştırıcı: None
Birincil Sonuç: inflammation markers
Etki Yönü: Mixed
Yanlılık Riski: Unclear

Abstract

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.

Kısaca

This work has suggested that brain‐gut axis may be another bridge from obesity to visceral hypersensitivity, and obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon.

Used In Evidence Reviews

C Vitamin D için Irritable Bowel Syndrome (IBS)

The interaction between obesity and visceral hypersensitivity.

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Study Design

Abstract

Kısaca

Used In Evidence Reviews

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