Lactobacillus reuteri için Gastroesophageal Reflux Disease (GERD)

Q: Does Lactobacillus reuteri help with Gastroesophageal Reflux Disease (GERD)?

Based on 2 studies with 250 participants, there is limited but promising evidence that Lactobacillus reuteri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is C (Some Evidence).

Q: How much Lactobacillus reuteri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus reuteri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

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Sonuç

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo Etki: None < 0.05

Review

The evidence for probiotics in the treatment of digestive disorders in the pediatric population.

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: Pediatric population

Key Statistics

Çalışmalar

250

Katılımcılar

↑

Positive

Derece

Referenced Papers

The evidence for probiotics in the treatment of digestive disorders in the pediatric population. Review

Journal of gastroenterology … 2025 10 atıf

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

general:: 100 million - 5 billion CFU/day
infantilecolic:: 100 million CFU/day (DSM 17938 strain, 5 drops)
adultgisupport:: 1-5 billion CFU/day

Üst sınır: Well-tolerated up to 10 billion CFU/day in clinical trials

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
None	--	Mixed	--

En iyi alım zamanı: Before meals or on empty stomach; for infants, add drops to breast milk or formula

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Mild gas in initial days of use
⚠ Occasional increased fussiness in infants during adjustment (transient)
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

Bilinen Etkileşimler

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Proton pump inhibitors (altered gastric pH may affect colonization)

Tolere edilebilir üst alım: Well-tolerated up to 10 billion CFU/day in clinical trials

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Lactobacillus reuteri help with Gastroesophageal Reflux Disease (GERD)?

Based on 2 studies with 250 participants, there is limited but promising evidence that Lactobacillus reuteri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is C (Some Evidence).

How much Lactobacillus reuteri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus reuteri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

Şu durum için diğer içerikler: Gastroesophageal Reflux Disease (GERD)

Lactobacillus gasseri D Ginger D Slippery Elm D

Lactobacillus reuteri diğer sağlık durumları için

Bloating and Intestinal Gas B

Hızlı Değerlendirme

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

Evidence Strength52%

Moderate confidence

Çalışma Dağılımı

RCT (0)Meta (0)Other (2)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Gastroesophageal Reflux Disease (GERD)

Daha Fazla Bilgi

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