The interaction between obesity and visceral hypersensitivity.

Wu Yanping, Xuefen Gao, Yizun Cheng, Mi Liu, Siyu Liao et al.

Review Journal of gastroenterology and hepatology 2023 16 citações

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Study Design

Tipo de Estudo: Review
População: None

Intervenção: The interaction between obesity and visceral hypersensitivity. None
Comparador: None
Desfecho Primário: inflammation markers
Direção do Efeito: Mixed
Risco de Viés: Unclear

Abstract

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.

Resumo Rápido

This work has suggested that brain‐gut axis may be another bridge from obesity to visceral hypersensitivity, and obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon.

Used In Evidence Reviews

C Vitamin D para Irritable Bowel Syndrome (IBS)

The interaction between obesity and visceral hypersensitivity.

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Study Design

Abstract

Resumo Rápido

Used In Evidence Reviews

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