What is the recommended dosage for Deglycyrrhizinated Licorice (DGL)?

General: 380-760 mg DGL extract 3 times daily before meals; Gastric Support: 760 mg before meals and at bedtime; Dyspepsia Support: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily

What are the side effects of Deglycyrrhizinated Licorice (DGL)?

Potential side effects include: Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects), Mild nausea in rare cases, Headache (uncommon), If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product).

What is deglycyrrhizinated licorice (DGL) and how does it work for gut health?

DGL is a processed form of licorice root with glycyrrhizin removed to prevent side effects like elevated blood pressure. It may help protect the stomach and esophageal lining by stimulating mucus production and promoting the growth of protective mucosal cells. Research suggests DGL may support healing of the gastric lining and help manage symptoms of heartburn and indigestion.

What is the recommended dosage of DGL?

The typical dosage is 380-760 mg of DGL taken 20 minutes before meals, 2-3 times daily. Chewable tablets are traditionally preferred as the act of chewing may stimulate salivary epidermal growth factor, which can further support mucosal healing. Some clinicians recommend taking DGL for 8-16 weeks for optimal results.

Are there side effects or interactions with DGL?

Because glycyrrhizin has been removed, DGL is significantly safer than whole licorice root and does not typically cause hypertension or potassium depletion. Side effects are rare and mild. However, individuals should verify that their DGL product has been properly deglycyrrhizinated. DGL may interact with certain medications, so consulting a healthcare provider is still recommended.

Deglycyrrhizinated Licorice (DGL)
Deglycyrrhizinated Licorice (DGL)

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Também conhecido como: DGL, Deglycyrrhizinated Glycyrrhiza glabra, GutGard, DGL Licorice

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About

Deglycyrrhizinated licorice (DGL) is a specially processed form of licorice root with the glycyrrhizin compound removed to prevent aldosterone-like side effects (hypertension, hypokalemia). DGL may help stimulate mucus and bicarbonate secretion in the gastric lining and enhance prostaglandin E2 production, which supports mucosal integrity. Research suggests it may support digestive comfort in functional dyspepsia and provide protective support for the gastric lining.

How It Works

Stimulates mucus and bicarbonate secretion in the gastric lining strengthening the mucosal defense barrier; enhances prostaglandin E2 production protecting mucosal integrity; promotes epithelial cell proliferation supporting mucosal repair; glycyrrhizin removed to prevent mineralocorticoid side effects.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Functional Dyspepsia	C	3	200	Ver →
Peptic Ulcer Disease	C	2	150	Ver →

Side Effects

Generally very well-tolerated (glycyrrhizin removal reduces risk of major side effects)
Mild nausea in rare cases
Headache (uncommon)
If glycyrrhizin is NOT fully removed: hypertension, hypokalemia, edema (ensure true DGL product)

Drug & Supplement Interactions

Digoxin (if residual glycyrrhizin present, hypokalemia may increase digoxin toxicity)
Diuretics (if residual glycyrrhizin, additive potassium loss)
Corticosteroids (if residual glycyrrhizin, additive mineralocorticoid effects)
Warfarin (theoretical interaction if residual glycyrrhizin affects metabolism)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Curcumin Peppermint Oil Ginger Berberine Slippery Elm

Dados Rápidos

Dosagem: General: 380-760 mg DGL extract 3 times daily before meals; Gastric_Support: 760 mg before meals and at bedtime; Dyspepsia_Support: 380-400 mg chewable tablet 20 minutes before meals, 3 times daily
Formas: chewable tablet (preferred) capsule powder liquid extract
Fontes Naturais: Licorice root (Glycyrrhiza glabra) — processed to remove glycyrrhizin
Limite Superior: Not established for DGL specifically; DGL removes the toxic glycyrrhizin component
Melhor Horário: 20 minutes before meals; chewable tablets should be chewed thoroughly for mucosal contact

Resumo das Evidências

Functional Dyspepsia C

Peptic Ulcer Disease C

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.