Lactobacillus reuteri para Gastroesophageal Reflux Disease (GERD)

Q: Does Lactobacillus reuteri help with Gastroesophageal Reflux Disease (GERD)?

Based on 2 studies with 250 participants, there is limited but promising evidence that Lactobacillus reuteri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is C (Some Evidence).

Q: How much Lactobacillus reuteri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lactobacillus reuteri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

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Conclusão

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

Key Study Findings

basic science

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Dose: Lactobacillus reuteri E9 (dose not specified) vs: Placebo Efeito: None < 0.05

Review

The evidence for probiotics in the treatment of digestive disorders in the pediatric population.

Dose: None vs: None Outcome: None Efeito: None None

População: Pediatric population

Key Statistics

Estudos

250

Participantes

↑

Positive

Nota

Referenced Papers

The evidence for probiotics in the treatment of digestive disorders in the pediatric population. Review

Journal of gastroenterology … 2025 10 citações

Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. Other

Frontiers in bioscience … 2025

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 100 million - 5 billion CFU/day
infantilecolic:: 100 million CFU/day (DSM 17938 strain, 5 drops)
adultgisupport:: 1-5 billion CFU/day

Limite superior: Well-tolerated up to 10 billion CFU/day in clinical trials

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
Lactobacillus reuteri E9 (dose not specified)	--	Positive	--
None	--	Mixed	--

Melhor horário: Before meals or on empty stomach; for infants, add drops to breast milk or formula

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Mild gas in initial days of use
⚠ Occasional increased fussiness in infants during adjustment (transient)
⚠ Rare loose stools
⚠ Very rare: bacteremia in immunocompromised individuals

Interações Conhecidas

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)
● Proton pump inhibitors (altered gastric pH may affect colonization)

Ingestão máxima tolerável: Well-tolerated up to 10 billion CFU/day in clinical trials

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Lactobacillus reuteri help with Gastroesophageal Reflux Disease (GERD)?

Based on 2 studies with 250 participants, there is limited but promising evidence that Lactobacillus reuteri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is C (Some Evidence).

How much Lactobacillus reuteri should I take for Gastroesophageal Reflux Disease (GERD)?

Studies have used various dosages. A commonly studied range is 100 million - 5 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus reuteri?

Reported side effects may include Mild gas in initial days of use, Occasional increased fussiness in infants during adjustment (transient), Rare loose stools, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus reuteri and Gastroesophageal Reflux Disease (GERD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Gastroesophageal Reflux Disease (GERD)

Lactobacillus gasseri D Ginger D Slippery Elm D

Lactobacillus reuteri para outras condições

Bloating and Intestinal Gas B

Veredito Rápido

Limited evidence that L. reuteri improves regurgitation in infants. Adult GERD evidence is weak.

Evidence Strength52%

Moderate confidence

Detalhamento dos Estudos

RCT (0)Meta (0)Other (2)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Gastroesophageal Reflux Disease (GERD)

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.