Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial.

Giancarlo Parisi, Enrico Bottona, Maurizio Carrara, Fabrizio Cardin, Alessandra Faedo et al.

RCT Digestive diseases and sciences 2005 55 citations

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Study Design

Study Type: Randomized Controlled Trial
Sample Size: 86
Population: IBS patients
Duration: 12 weeks

Intervention: Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial. PHGG 5g/day or 10g/day
Comparator: Baseline comparison
Primary Outcome: GSRS, SF-36, HADS scores
Effect Direction: Positive
Risk of Bias: Moderate

Abstract

The effects of partially hydrolyzed guar gum (PHGG) were compared in patients with irritable bowel syndrome, at 10 g/day (N = 40) and 5 g/day (N = 46) for 12 weeks. Gastrointestinal symptoms (GSRS), quality of life (SF-36), and psychological symptoms (HADS) were evaluated at baseline, during treatment (months 1 and 3), and at follow-up (month 6). In both groups symptoms and quality of life improved significantly after the first month of administration until follow-up compared to those at baseline. However, the improvement was significantly reduced at follow-up compared to the end of treatment. PHGG was effective for improving somatic (gastrointestinal symptoms) and psychological (quality of life and psychological distress) symptoms over the short term. Since the improvement tended to decrease after the end of the treatment period, further studies should evaluate the benefits of PHGG at a maintenance dosage.

TL;DR

In patients with irritable bowel syndrome symptoms and quality of life improved significantly after the first month of administration until follow-up compared to those at baseline, but the improvement was significantly reduced at follow- up compared to the end of treatment.

Used In Evidence Reviews

B Partially Hydrolyzed Guar Gum (PHGG) for Irritable Bowel Syndrome (IBS)

Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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