Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial.

Giancarlo Parisi, Enrico Bottona, Maurizio Carrara, Fabrizio Cardin, Alessandra Faedo et al.

RCT Digestive diseases and sciences 2005 55 citations

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Study Design

Type d'étude: Randomized Controlled Trial
Taille de l'échantillon: 86
Population: IBS patients
Durée: 12 weeks

Intervention: Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial. PHGG 5g/day or 10g/day
Comparateur: Baseline comparison
Critère de jugement principal: GSRS, SF-36, HADS scores
Direction de l'effet: Positive
Risque de biais: Moderate

Abstract

The effects of partially hydrolyzed guar gum (PHGG) were compared in patients with irritable bowel syndrome, at 10 g/day (N = 40) and 5 g/day (N = 46) for 12 weeks. Gastrointestinal symptoms (GSRS), quality of life (SF-36), and psychological symptoms (HADS) were evaluated at baseline, during treatment (months 1 and 3), and at follow-up (month 6). In both groups symptoms and quality of life improved significantly after the first month of administration until follow-up compared to those at baseline. However, the improvement was significantly reduced at follow-up compared to the end of treatment. PHGG was effective for improving somatic (gastrointestinal symptoms) and psychological (quality of life and psychological distress) symptoms over the short term. Since the improvement tended to decrease after the end of the treatment period, further studies should evaluate the benefits of PHGG at a maintenance dosage.

En bref

In patients with irritable bowel syndrome symptoms and quality of life improved significantly after the first month of administration until follow-up compared to those at baseline, but the improvement was significantly reduced at follow- up compared to the end of treatment.

Used In Evidence Reviews

B Partially Hydrolyzed Guar Gum (PHGG) pour Irritable Bowel Syndrome (IBS)

Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial.

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Study Design

Abstract

En bref

Used In Evidence Reviews

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