What is the recommended dosage for Saccharomyces boulardii?

General: 250-500 mg/day (equivalent to 5-10 billion CFU); Aad Prevention: 500 mg/day (start with antibiotic, continue 7 days after); C Diff Prevention: 500 mg twice daily as adjunct to standard therapy; Travelers Diarrhea: 250-500 mg/day starting 5 days before travel

What are the side effects of Saccharomyces boulardii?

Potential side effects include: Mild gas and bloating, Rare: fungemia in critically ill patients with central venous catheters, Thirst (yeast may increase water requirements), Very rare: potential environmental contamination risk in ICU settings.

What is Saccharomyces boulardii and how does it work for gut health?

Saccharomyces boulardii is a beneficial yeast (not a bacterium) that has been used as a probiotic since the 1950s. Unlike bacterial probiotics, it is naturally resistant to antibiotics, making it particularly useful during antibiotic therapy. It works by producing proteases that neutralize bacterial toxins, strengthening intestinal barrier function, and modulating the immune response. It is one of the most evidence-supported probiotics for diarrheal conditions.

What is the recommended dosage of Saccharomyces boulardii?

The standard clinical dosage is 250-500 mg (equivalent to 5-10 billion CFU) taken 1-2 times daily. The strain S. boulardii CNCM I-745 (marketed as Florastor) is the most extensively studied. For preventing antibiotic-associated diarrhea, it should be started on the first day of antibiotic therapy and continued for 2 weeks after antibiotics are completed.

Are there side effects or interactions with Saccharomyces boulardii?

S. boulardii is generally well-tolerated with a good safety profile. Rarely, it may cause gas or bloating. It should be avoided in patients with central venous catheters due to rare reports of fungemia. Because it is a yeast, it is resistant to antibacterial antibiotics but susceptible to antifungal medications like fluconazole — so it should not be taken concurrently with antifungal drugs.

Saccharomyces boulardii
Saccharomyces boulardii

probiotic_strain

別名: S. boulardii, CNCM I-745, Florastor, Saccharomyces cerevisiae var. boulardii

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About

Saccharomyces boulardii is a non-pathogenic tropical yeast that supports digestive health through multiple mechanisms. Unlike bacterial probiotics, it is naturally resistant to antibiotics, making it uniquely suited for use alongside antibiotic therapy. Research suggests it may help support the body's defense against C. difficile by secreting a protease that degrades toxins A and B, while also enhancing secretory IgA production and stimulating brush border enzyme activity.

How It Works

Non-pathogenic yeast that secretes a 54-kDa protease degrading C. difficile toxins A and B; enhances secretory IgA production protecting mucosal surfaces; stimulates brush border enzymes (lactase, sucrase, maltase); naturally resistant to all antibacterial antibiotics.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Antibiotic-Associated Diarrhea (AAD)	A	25	5000	詳細を見る →
Clostridioides difficile Infection (CDI)	B	6	3000	詳細を見る →
Traveler's Diarrhea	B	4	3200	詳細を見る →

Side Effects

Mild gas and bloating
Rare: fungemia in critically ill patients with central venous catheters
Thirst (yeast may increase water requirements)
Very rare: potential environmental contamination risk in ICU settings

Drug & Supplement Interactions

Antifungal medications (may kill S. boulardii, reducing effectiveness)
Monoamine oxidase inhibitors (S. boulardii contains tyramine)
Immunosuppressants (theoretical risk of fungemia in immunocompromised patients)

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Related Ingredients

Bifidobacterium longum Bifidobacterium bifidum Lactobacillus gasseri Lactobacillus casei Bifidobacterium lactis

基本情報

用量: General: 250-500 mg/day (equivalent to 5-10 billion CFU); Aad_Prevention: 500 mg/day (start with antibiotic, continue 7 days after); C_Diff_Prevention: 500 mg twice daily as adjunct to standard therapy; Travelers_Diarrhea: 250-500 mg/day starting 5 days before travel
剤形: capsule powder sachet
天然の供給源: Originally isolated from lychee and mangosteen fruit skins, Available primarily as commercial supplements
上限量: Well-tolerated up to 1,000 mg/day in clinical trials
推奨摂取タイミング: Can be taken with or without food; space 2 hours from antifungals

エビデンスの要約

Antibiotic-Associated Diarrhea (AAD) A

Clostridioides difficile Infection (CDI) B

Traveler's Diarrhea B

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。