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GutCited

Peppermint Oil
Peppermint Oil

herb

別名: Mentha x piperita Oil, IBgard, Colpermin, Mintec

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About





            

                
Peppermint oil is one of the most robustly studied herbal interventions for IBS, supported by Cochrane-quality meta-analyses. Its active component, menthol, blocks calcium channels in intestinal smooth muscle to produce an antispasmodic effect and activates TRPM8 cold receptors that may help reduce visceral pain perception. Research suggests enteric-coated peppermint oil capsules may significantly reduce IBS-related abdominal pain and improve overall symptom scores.

            

        

        

        
        
        

            

  
How It Works





            

                
Menthol blocks L-type calcium channels in intestinal smooth muscle causing antispasmodic relaxation; activates TRPM8 cold receptors reducing visceral pain perception; speeds early-phase gastric emptying while reducing colonic motility; antimicrobial activity against enteric pathogens.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                症状・状態
                                グレード
                                研究数
                                参加者数
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Irritable Bowel Syndrome (IBS)
                                    
                                
                                
                                    A

                                
                                
                                    19
                                
                                
                                    2569
                                
                                
                                    
                                        詳細を見る →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Heartburn/GERD exacerbation (if non-enteric-coated; relaxes lower esophageal sphincter)
                
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                    Perianal burning sensation (from undigested menthol reaching the rectum)
                
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                    Nausea at high doses
                
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                    Allergic reactions in mint-sensitive individuals
                
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Drug & Supplement Interactions





            
    
                
                
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                    Cyclosporine (peppermint may increase cyclosporine levels via CYP3A4 inhibition)
                
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                    Antacids and PPIs (may dissolve enteric coating prematurely; space 2 hours)
                
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                    Simethicone (coated formulations may interact with enteric-coated peppermint)
                
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                    CYP2C19 substrates (menthol is a weak CYP inhibitor)
                
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                服用しているすべてのサプリメントについて、必ず医療提供者にお知らせください。摂取しているすべてのサプリメントについて、必ず医療専門家にお知らせください。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Curcumin
                    
                
                
                
                    Ginger
                    
                
                
                
                    Berberine
                    
                
                
                
                    Slippery Elm
                    
                
                
                
                    Deglycyrrhizinated Licorice (DGL)
                    
                
                
            

        

        
    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。