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Butyrate (Sodium/Calcium Butyrate)
Butyrate (Sodium/Calcium Butyrate)

fatty_acid

別名: Sodium Butyrate, Calcium Butyrate, Butyric Acid, Tributyrin, ButyrEn

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About





            

                
Butyrate is a short-chain fatty acid (SCFA) that serves as the primary energy source for colonocytes, providing approximately 70% of their energy needs. It may help inhibit NF-kB signaling to support a healthy colonic inflammatory response, promote regulatory T cell differentiation, and enhance tight junction assembly and mucus layer thickness via HDAC inhibition. Research suggests oral butyrate supplementation may support symptom management in inflammatory bowel conditions.

            

        

        

        
        
        

            

  
How It Works





            

                
Primary energy source for colonocytes providing approximately 70% of cellular energy; inhibits NF-kB transcription factor reducing colonic inflammation; promotes regulatory T cell differentiation via HDAC inhibition; enhances tight junction assembly (claudin-1, ZO-1) and stimulates mucus layer thickness; activates GPR109A (HCAR2) anti-inflammatory signaling.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                症状・状態
                                グレード
                                研究数
                                参加者数
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Ulcerative Colitis (UC)
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    390
                                
                                
                                    
                                        詳細を見る →
                                    
                                
                            

                            
                            

                                
                                    
                                        Crohn's Disease
                                    
                                
                                
                                    C

                                
                                
                                    2
                                
                                
                                    200
                                
                                
                                    
                                        詳細を見る →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
  • 
                    
                    Unpleasant taste/odor (butyric acid has a strong rancid butter smell)
                
    • 
                
                
  • 
                    
                    Mild GI discomfort (nausea, bloating)
                
    • 
                
                
  • 
                    
                    Belching with butyric acid odor
                
    • 
                
                
  • 
                    
                    Enteric-coated formulations reduce taste issues
                
    • 
                
            

        

        

        
        
        

            

  
Drug & Supplement Interactions





            
    
                
                
  • 
                    
                    5-ASA medications (mesalamine) — additive anti-inflammatory effect (potentially beneficial in IBD)
                
    • 
                
                
  • 
                    
                    No significant adverse drug interactions known
                
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Related Ingredients





            

                
                
                    Omega-3 Fatty Acids (EPA/DHA)
                    
                
                
                
                    Medium-Chain Triglycerides (MCT Oil)
                    
                
                
            

        

        
    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。