The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases.

Karolina Kaźmierczak-Siedlecka, Agnieszka Daca, Marcin Folwarski, Jacek M Witkowski, Ewa Bryl et al.

Review Central-European journal of immunology 2020 38 citazioni

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Study Design

Tipo di studio: Review
Popolazione: IBS patients

Intervento: The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases. None
Comparatore: None
Esito primario: None
Direzione dell'effetto: Positive
Rischio di bias: Unclear

Abstract

Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

TL;DR

The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens, which provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain.

Used In Evidence Reviews

B Lactobacillus plantarum per Irritable Bowel Syndrome (IBS)

The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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