Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease.

Margherita T Cantorna, Kaitlin McDaniel, Stephanie Bora, Jing Chen, Jamaal James

Review Experimental biology and medicine (Maywood, N.J.) 2014 131 citazioni

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Study Design

Tipo di studio: Review
Popolazione: IBD patients

Intervento: Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. None
Comparatore: None
Esito primario: None
Direzione dell'effetto: Positive
Rischio di bias: Unclear

Abstract

The inflammatory bowel diseases are complex diseases caused by environmental, immunological, and genetic factors. Vitamin D status is low in patients with inflammatory bowel diseases, and experimental inflammatory bowel diseases are more severe in vitamin D-deficient or vitamin D receptor knockout animals. Vitamin D is beneficial in inflammatory bowel diseases because it regulates multiple checkpoints and processes essential for homeostasis in the gut. Vitamin D inhibits IFN-γ and IL-17 production while inducing regulatory T cells. In addition, vitamin D regulates epithelial cell integrity, innate immune responses, and the composition of the gut microbiota. Overall, vitamin D regulates multiple pathways that maintain gastrointestinal homeostasis. The data support improving vitamin D status in patients with inflammatory bowel diseases.

TL;DR

The data support improving vitamin D status in patients with inflammatory bowel diseases and suggest vitamin D regulates multiple pathways that maintain gastrointestinal homeostasis.

Used In Evidence Reviews

B Vitamin D per Inflammatory Bowel Disease (IBD) — General

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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