An in vitro assessment of the effects of broad-spectrum antibiotics on the human gut microflora and concomitant isolation of a Lactobacillus plantarum with anti-Candida activities.

Anthony G Wynne, Anne L McCartney, Jonathan Brostoff, Barry N Hudspith, Glenn R Gibson

Other Anaerobe 2004 40 citazioni

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Study Design

Tipo di studio: In Vitro
Popolazione: Human gut microflora in chemostat culture

Intervento: An in vitro assessment of the effects of broad-spectrum antibiotics on the human gut microflora and concomitant isolation of a Lactobacillus plantarum with anti-Candida activities. Tetracycline, nystatin
Comparatore: Control culture
Esito primario: Gut microflora populations
Direzione dell'effetto: Negative
Rischio di bias: Unclear

Abstract

Chemostat culture was used to determine the effects of the antimicrobial agents tetracycline and nystatin on predominant components of the human gut microflora. Their addition to mixed culture systems caused a non-specific, and variable, decrease in microbial populations, although tetracycline allowed an increase in numbers of yeasts. Both had a profound inhibitory effect upon populations seen as important for gut health (bifidobacteria, lactobacilli). However, a tetracycline resistant Lactobacillus was enriched from the experiments. A combination of genotypic and phenotypic characterisation confirmed its identity as Lactobacillus plantarum. This strain exerted powerful inhibitory effects against Candida albicans. Because of its ability to resist the effects of tetracycline, this organism may be useful as a probiotic for the improved management of yeast related conditions such as thrush and irritable bowel syndrome.

TL;DR

Because of its ability to resist the effects of tetracycline, this organism may be useful as a probiotic for the improved management of yeast related conditions such as thrush and irritable bowel syndrome.

Used In Evidence Reviews

B Lactobacillus plantarum per Irritable Bowel Syndrome (IBS)

An in vitro assessment of the effects of broad-spectrum antibiotics on the human gut microflora and concomitant isolation of a Lactobacillus plantarum with anti-Candida activities.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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