Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.

Bohuslav Melichar, Josef Dvorák, Lenka Krcmová, Radomír Hyspler, Lubor Urbánek et al.

Other American journal of clinical oncology 2008 25 citations

<\/script>\n

`; }, get iframeSnippet() { const domain = 'gutcited.com'; const params = 'pmid\u003D19060591'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

Type d'étude: Other
Taille de l'échantillon: 11
Population: None

Intervention: Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. None
Comparateur: None
Critère de jugement principal: Gastrointestinal toxicity is one of the most common side effects of anticancer t
Direction de l'effet: Mixed
Risque de biais: Moderate

Abstract

OBJECTIVE: Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID). METHODS: We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test. RESULTS: Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID. CONCLUSIONS: Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.

En bref

Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID and were decreased significantly in patients with CID.

Used In Evidence Reviews

C Vitamin A pour Increased Intestinal Permeability (Leaky Gut)

D Vitamin A pour Acute Diarrhea

Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.

Embed This Widget

Study Design

Abstract

En bref

Used In Evidence Reviews

Similar Papers

The immune system: a target for functional foods?

Diet and nutritional factors in inflammatory bowel diseases.

Influence of mineral and vitamin supplements on pregnancy outcome.

Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children.

Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania.

Impact of massive dose of vitamin A given to preschool children with acute diarrhoea on subsequent respiratory and diarrhoeal morbidity.