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Lactobacillus gasseri für Gastroesophageal Reflux Disease (GERD)

D

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

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D

Fazit

Emerging evidence from Japanese studies. May reduce acid-related symptoms. Not yet replicated in Western populations.

Key Study Findings

Meta-Analysis
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome.
Dose: None vs.: placebo Outcome: improvement in key IBS symptoms Wirkung: None None

Population: patients with IBS from 32 RCTs evaluating 10 probiotic strains

In Vitro
Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in …
Dose: None vs.: H. pylori infection without lactobacilli Outcome: ADAM17, HBEGF, TGF-alpha expression Wirkung: None None

Population: AGS gastric epithelial cells and mouse model

In Vitro
The modulatory effect of Lactobacillus gasseri ATCC 33323 on autophagy induced by extracellular vesicles of …
Dose: 50 μg/ml vs.: None Outcome: Inflammatory markers Wirkung: None None

Population: None

Other
Effect of Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 on Gastric Carcinogenesis Induced by Helicobacter …
Dose: None vs.: None Outcome: Inflammatory markers Wirkung: None None

Population: Cancer patients

In Vitro
Effects of Glutamine, Curcumin and Fish Bioactive Peptides Alone or in Combination on Intestinal Permeability …
Dose: None vs.: None Outcome: inflammation markers Wirkung: None None

Population: Mice

Case-Control n=178
Oral and gastric microbiome in relation to gastric intestinal metaplasia.
Dose: None vs.: None Outcome: Oral/gastric microbiome associations with IM Wirkung: None None

Population: Gastric intestinal metaplasia cases and matched controls

Key Statistics

3

Studien

300

Teilnehmer

Positive

D

Bewertung

Referenced Papers

International journal of … 2022 59 Zitierungen
Comparative immunology, microbiology … 2019 72 Zitierungen
Probiotics and antimicrobial … 2010 9 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
1-10 billion CFU/day
gerdsupport:
1-5 billion CFU/day
hpylorisupport:
100 million CFU/day (LG21 strain, yogurt form) for 8-12 weeks

Obergrenze: Well-tolerated up to 10 billion CFU/day in clinical trials

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Positive --
None -- Positive --
50 μg/ml -- Mixed --
None -- Positive --
None -- Mixed --
None -- Neutral 178
None -- Positive --
None -- Positive --

Beste Einnahmezeit: Before meals or with meals; yogurt form taken with food

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Mild gas during initial use
  • Occasional loose stools
  • Rare abdominal discomfort
  • Very rare: bacteremia in immunocompromised individuals

Bekannte Wechselwirkungen

  • Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
  • Proton pump inhibitors (altered gastric pH may affect colonization)
  • Immunosuppressants (theoretical risk in immunocompromised patients)

Tolerierbare Höchstaufnahmemenge: Well-tolerated up to 10 billion CFU/day in clinical trials

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Lactobacillus gasseri help with Gastroesophageal Reflux Disease (GERD)?
Based on 3 studies with 300 participants, there is preliminary evidence that needs more research that Lactobacillus gasseri may support Gastroesophageal Reflux Disease (GERD) management. Our evidence grade is D (Very Early Research).
How much Lactobacillus gasseri should I take for Gastroesophageal Reflux Disease (GERD)?
Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactobacillus gasseri?
Reported side effects may include Mild gas during initial use, Occasional loose stools, Rare abdominal discomfort, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactobacillus gasseri and Gastroesophageal Reflux Disease (GERD)?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

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Lactobacillus gasseri für andere Beschwerden

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