What are the best supplements for gastric ulcers?

Zinc carnosine has the strongest evidence for supporting gastric mucosal healing, with prescription use in Japan since 1994. Deglycyrrhizinated licorice (DGL) may help stimulate protective mucus production, and mastic gum has shown some evidence for H. pylori-associated ulcers. Probiotics, particularly Lactobacillus reuteri, may support ulcer healing when combined with standard H. pylori eradication therapy.

Can supplements alone manage gastric ulcers?

Gastric ulcers require proper medical diagnosis and treatment. If caused by H. pylori, antibiotic eradication therapy is essential. If caused by NSAIDs, discontinuation or reduction of the offending medication is the primary treatment. Proton pump inhibitors are the standard of care for healing ulcers. Supplements like zinc carnosine and DGL may support healing as adjuncts to conventional treatment but should not replace medical therapy.

When should I see a doctor for gastric ulcer symptoms?

Seek immediate medical attention if you experience sudden, severe abdominal pain (which may indicate perforation), vomiting blood or material that looks like coffee grounds, black tarry stools, or feeling faint. These are signs of potentially life-threatening complications. See a doctor promptly for persistent burning or gnawing stomach pain, especially if it worsens when your stomach is empty or is relieved by eating or antacids.

Peptic Ulcer Disease

Prevalence: 5-10% lifetime prevalence; declining due to H. pylori treatment

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Evidence-Ranked Ingredients

Ingredient	Grade	Studies	Direction
Zinc Carnosine	B	6	Positive	View →
Deglycyrrhizinated Licorice (DGL)	C	2	Positive	View →

About

Defects in the gastric or duodenal mucosa extending through the muscularis mucosae, caused primarily by H. pylori infection (60-70%) or NSAID use (20-25%). Gastric acid and pepsin erode mucosa when protective mechanisms (mucus, bicarbonate, prostaglandins, blood flow) are impaired.

Common Symptoms

Epigastric pain (burning, gnawing) Pain worse with empty stomach (duodenal) or after meals (gastric) Nausea Bloating Early satiety

Risk Factors

H. pylori infection
NSAID use
Smoking
Alcohol
Stress
Family history
Zollinger-Ellison syndrome

Frequently Asked Questions

What supplements may help with Peptic Ulcer Disease?

Based on peer-reviewed research, supplements with the strongest evidence for Peptic Ulcer Disease include Zinc Carnosine. These have earned Grade A or B ratings from our analysis of clinical studies. Always consult your healthcare provider before starting any supplement.

How is the evidence for Peptic Ulcer Disease supplements graded?

We grade supplements on an A-F scale based on clinical study quality, consistency of results, sample sizes, and study design. Grade A indicates strong evidence from multiple clinical trials, while Grade D indicates preliminary evidence requiring further research.

How many studies on Peptic Ulcer Disease supplements have been reviewed?

Our evidence grades for Peptic Ulcer Disease are based on a total of 8 peer-reviewed studies across 2 ingredients. Studies are sourced from PubMed and include randomized controlled trials, meta-analyses, and other clinical research.

What are common symptoms of Peptic Ulcer Disease?

Common symptoms associated with Peptic Ulcer Disease include Epigastric pain (burning, gnawing), Pain worse with empty stomach (duodenal) or after meals (gastric), Nausea, Bloating, Early satiety. If you are experiencing these symptoms, consult a healthcare professional for proper diagnosis and treatment options.

Related Conditions

Conditions that share studied ingredients

Functional Dyspepsia Increased Intestinal Permeability (Leaky Gut)

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.