Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome.

Qiao-Yan Gu, Jun Zhang, Yi-Chao Feng

Other Artificial cells, nanomedicine, and biotechnology 2016 16 اقتباسات

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Study Design

نوع الدراسة: Other
حجم العينة: 10
المجتمع المدروس: IBS patients

التدخل: Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome. None
المقارن: control
النتيجة الأولية: None
اتجاه التأثير: Positive
خطر التحيز: Unclear

Abstract

We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n = 10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Significantly more IL-18 and IL-1β were expressed in PI-2W and PI-8W groups than those in normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1β expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.

باختصار

Bifidobacterium longum may down-regulate IL-18 and IL-1β expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.

Used In Evidence Reviews

B Bifidobacterium longum لـ Irritable Bowel Syndrome (IBS)

Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome.

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Study Design

Abstract

باختصار

Used In Evidence Reviews

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