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Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of alpha-linolenic acid (ALA) and inflammatory bowel disease (IBD). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias.
Figure 289
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Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study.Cite This Figure
![Figure 289: Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of alpha-linolenic acid (ALA) and inflammatory bowel disease (IBD). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias.]() > Source: Xiaojing Jia et al. "Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bo." *Metabolites*, 2023. PMID: [37887366](https://pubmed.ncbi.nlm.nih.gov/37887366/)
<figure> <img src="" alt="Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of alpha-linolenic acid (ALA) and inflammatory bowel disease (IBD). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias." /> <figcaption>Figure 289. Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of alpha-linolenic acid (ALA) and inflammatory bowel disease (IBD). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias.<br> Source: Xiaojing Jia et al. "Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bo." <em>Metabolites</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37887366/">37887366</a></figcaption> </figure>