Lactobacillus casei cho Antibiotic-Associated Diarrhea (AAD)

Some evidence for AAD prevention in hospitalized elderly patients (PLACIDE trial was negative for primary outcome but showed trends).

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Kết luận

Some evidence for AAD prevention in hospitalized elderly patients (PLACIDE trial was negative for primary outcome but showed trends).

Key Study Findings

In Vitro

Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice.

Dose: 4-strain probiotic mixture so với: Ampicillin-induced AAD model Outcome: Gut microbiota recovery and immune modulation Hiệu quả: None None

Đối tượng nghiên cứu: Ampicillin-induced AAD mouse model

Meta-Analysis n=692

Which probiotic has the best effect on preventing Clostridium difficile-associated diarrhea? A systematic review and …

Dose: None so với: Control group Outcome: the incidence rates of AAD and CDAD, and … Hiệu quả: OR 0.39, None

Đối tượng nghiên cứu: Diarrhea patients

Randomized Controlled Trial n=314 4.3 weeks Double-blind

Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial.

Dose: None so với: Placebo Outcome: Bowel function Hiệu quả: None p=0.30

Đối tượng nghiên cứu: None

Systematic Review n=228

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis.

Dose: None so với: None Outcome: Diarrhea outcomes Hiệu quả: None None

Đối tượng nghiên cứu: None

Controlled Clinical Trial n=32 4.3 weeks Open-label

Feasibility of a Lactobacillus casei Drink in the Intensive Care Unit for Prevention of Antibiotic …

Dose: 10 billion L. casei, 2 bottles/day so với: Contemporary matched controls Outcome: Safety, feasibility, AAD incidence Hiệu quả: None None

Đối tượng nghiên cứu: ICU patients on antibiotics

Meta-Analysis n=9569

Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis.

Dose: None so với: Placebo/no probiotic Outcome: Prevention of antibiotic-associated diarrhea Hiệu quả: LGG OR 0.28 (0.17-0.47) for AAD prevention None

Đối tượng nghiên cứu: Patients on antibiotics

Key Statistics

Nghiên cứu

500

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice. Other

Frontiers in microbiology 2023 21 trích dẫn

Which probiotic has the best effect on preventing Clostridium difficile-associated diarrhea? A systematic review and network meta-analysis. Meta-Analysis

Journal of digestive … 2020 43 trích dẫn

Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial. RCT

Journal of clinical … 2019 17 trích dẫn

Strain-Specificity and Disease-Specificity of Probiotic Efficacy: A Systematic Review and Meta-Analysis. Other

Frontiers in medicine 2018 450 trích dẫn

Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis. Review

United European gastroenterology … 2018 66 trích dẫn

Feasibility of a Lactobacillus casei Drink in the Intensive Care Unit for Prevention of Antibiotic Associated Diarrhea and Clostridium difficile. CCT

Nutrients 2018 50 trích dẫn

Probiotics in critically ill children. Review

F1000Research 2016 63 trích dẫn

Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Review

Antibiotics (Basel, Switzerland) 2015 104 trích dẫn

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): Characterization, Manufacture, Mechanisms of Action, and Quality Control of … Review

Clinical infectious diseases … 2015 59 trích dẫn

Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea. RCT

World journal of … 2014 73 trích dẫn

Savings from the use of a probiotic formula in the prophylaxis of antibiotic-associated diarrhea. Other

Journal of medical … 2012 28 trích dẫn

The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial. RCT

Revista da Sociedade … 2012 13 trích dẫn

Probiotics for prevention and treatment of diarrhea. Review

Journal of clinical … 2011 432 trích dẫn

Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium … RCT

The American journal … 2010 313 trích dẫn

Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, … RCT

Canadian journal of … 2007 182 trích dẫn

In vitro antibiotic susceptibility of lactobacilli isolated from commercial products containing active lactobacilli. Other

Acta paediatrica Taiwanica … 2004 6 trích dẫn

Treatment and prevention of antibiotic associated diarrhea. Review

International journal of … 2000 181 trích dẫn

Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. RCT

The Journal of … 1999 559 trích dẫn

Pharmaceutical probiotics for the treatment of anaerobic and other infections. Other

Anaerobe 1997 40 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 1-10 billion CFU/day
aadprevention:: 6.5 billion CFU/day (Shirota strain)
immunesupport:: 10 billion CFU/day

Giới hạn trên: Well-tolerated up to 20 billion CFU/day in clinical trials

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
4-strain probiotic mixture	--	Positive	--
None	--	Positive	692
None	4.3 weeks	Neutral	314
None	--	Mixed	228
10 billion L. casei, 2 bottles/day	4.3 weeks	Positive	32
None	--	Positive	9569
None	--	Mixed	--
None	--	Positive	--

Thời điểm dùng tốt nhất: With or without food; consistent daily timing recommended

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Mild gas and bloating during initial use
⚠ Occasional loose stools
⚠ Rare dairy-related reactions in lactose-sensitive individuals
⚠ Very rare: bacteremia in immunocompromised individuals

Tương tác đã biết

● Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
● Immunosuppressants (theoretical risk in immunocompromised patients)

Mức hấp thụ tối đa cho phép: Well-tolerated up to 20 billion CFU/day in clinical trials

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Lactobacillus casei help with Antibiotic-Associated Diarrhea (AAD)?

Based on 3 studies with 500 participants, there is limited but promising evidence that Lactobacillus casei may support Antibiotic-Associated Diarrhea (AAD) management. Our evidence grade is C (Some Evidence).

How much Lactobacillus casei should I take for Antibiotic-Associated Diarrhea (AAD)?

Studies have used various dosages. A commonly studied range is 1-10 billion CFU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactobacillus casei?

Reported side effects may include Mild gas and bloating during initial use, Occasional loose stools, Rare dairy-related reactions in lactose-sensitive individuals, Very rare: bacteremia in immunocompromised individuals. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactobacillus casei and Antibiotic-Associated Diarrhea (AAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Antibiotic-Associated Diarrhea (AAD)

Saccharomyces boulardii A Lactobacillus rhamnosus GG A

Đánh giá nhanh

Some evidence for AAD prevention in hospitalized elderly patients (PLACIDE trial was negative for primary outcome but showed trends).

Evidence Strength52%

Moderate confidence

Phân tích nghiên cứu

RCT (6)Meta (1)Other (0)

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