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Lactobacillus rhamnosus GG
Lactobacillus rhamnosus GG

probiotic_strain

Diğer adları: LGG, Lacticaseibacillus rhamnosus GG, ATCC 53103

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About

Lactobacillus rhamnosus GG (LGG) is one of the most extensively studied probiotic strains in the world, with over 1,000 published clinical studies. It supports gut barrier function by upregulating tight junction proteins and may help modulate the intestinal immune response via Toll-like receptor signaling. Research suggests LGG may be particularly beneficial for antibiotic-associated digestive issues and supporting overall digestive comfort.

How It Works

Enhances gut barrier function by upregulating tight junction proteins (claudin-1, occludin, ZO-1) and modulates intestinal immune response via Toll-like receptor signaling; produces soluble factors p75 and p40 that activate Akt pathway in epithelial cells preventing cytokine-induced apoptosis.

Evidence For Conditions

Side Effects

  • Mild gas and bloating during initial use (usually resolves in 1-2 weeks)
  • Rare reports of bacteremia in severely immunocompromised individuals
  • Occasional loose stools during adjustment period
  • Very rare: systemic infection in critically ill patients with central venous catheters

Drug & Supplement Interactions

  • Antibiotics (may reduce probiotic viability; space dosing 2 hours apart)
  • Immunosuppressants (theoretical risk of infection in immunocompromised patients)
  • Antifungals (no known interaction but may affect gut flora balance)

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Related Ingredients

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