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Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of docosahexaenoic acid (DHA) and ulcerative colitis (UC). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias.
Figure 449
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Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study.Cite This Figure
![Figure 449: Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of docosahexaenoic acid (DHA) and ulcerative colitis (UC). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias.]() > Source: Xiaojing Jia et al. "Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bo." *Metabolites*, 2023. PMID: [37887366](https://pubmed.ncbi.nlm.nih.gov/37887366/)
<figure> <img src="" alt="Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of docosahexaenoic acid (DHA) and ulcerative colitis (UC). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias." /> <figcaption>Figure 449. Funnel plot evaluating potential directional pleiotropy in the Mendelian randomization analysis of docosahexaenoic acid (DHA) and ulcerative colitis (UC). Asymmetry in the distribution of individual SNP estimates around the overall effect size may indicate the presence of pleiotropic bias.<br> Source: Xiaojing Jia et al. "Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bo." <em>Metabolites</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37887366/">37887366</a></figcaption> </figure>