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N-Acetyl Cysteine (NAC) Рисунки

43 иллюстрации из рецензируемых исследований

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Fig. 1 Schematic illustration of turmeric-derived nanoparticles (TDNPs 2) isolation and targeted ulcerative colitis (UC) therapy via oral administration. A TDNPs 2 were isolated and purified from edible turmeric by ultracentrifugation and sucrose gradient
Figure 1 Diagram

Turmeric-derived nanoparticles (TDNPs 2) are isolated through sucrose gradient ultracentrifugation and administered orally to target inflamed colonic tissue in a murine colitis model. The schematic outlines the isolation workflow from edible turmeric to purified nanovesicles.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Fig. 2 Characterization of TDNPs. A TDNPs were isolated and purified by sucrose gradient ultracentrifugation, band 1 from 8%/30% interface was named TDNPs 1, and band 2 from 30%/45% interface was named TDNPs 2. B Transmission Electron Microscopy (TEM) to
Figure 2 Chart

Characterization of turmeric-derived nanoparticles reveals two distinct bands (TDNPs 1 and TDNPs 2) at the 8%/30% and 30%/45% sucrose gradient interfaces, respectively. TDNPs 2 demonstrate appropriate size distribution and surface charge for oral drug delivery applications.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Figure 3
Figure 3 Chart

In vitro assessment of turmeric-derived nanovesicles demonstrates anti-inflammatory activity, including suppression of pro-inflammatory cytokine production in activated macrophages. Dose-dependent reductions in TNF-alpha and IL-6 secretion are observed.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Fig. 4 TDNPs 2 preferentially localized to the inflamed colon. A Digestive tract, mesenteric lymph nodes (MLN), and vital organs (Heart, liver, spleen, lung, kidney, and) were imaged by IVIS® Spectrum imaging system. B–D FACS was used to determine the pop
Figure 4 Photograph

Biodistribution imaging using IVIS Spectrum reveals that TDNPs 2 preferentially accumulate in inflamed colonic tissue following oral administration. Fluorescence signals are minimal in non-target organs including heart, liver, spleen, lung, and kidney.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Figure 5
Figure 5 Chart

Oral TDNPs 2 administration significantly attenuates disease activity index scores and colon shortening in DSS-induced colitis mice. Body weight recovery is also improved compared to untreated colitis controls.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Figure 6
Figure 6 Chart

Intestinal permeability assessment indicates that TDNPs 2 treatment preserves gut barrier integrity in colitis mice. Tight junction protein expression, including ZO-1 and occludin, is maintained at near-normal levels.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Fig. 7 Histological stain to evaluate the protective effect of TDNPs 2 on colitis. A Representative H&E-stained colon. Inflammatory cell infiltration was indicated by arrowheads. B Colonic goblet cells were stained by Alcian blue. As goblet cells prod
Figure 7 Micrograph

Histological examination with H&E staining reveals markedly reduced inflammatory cell infiltration and preserved goblet cell density in TDNPs 2-treated colitic mice. Colonic tissue architecture remains largely intact compared to severe disruption in untreated animals.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Fig. 8 Oral administration of TDNPs 2 accelerated inflammation resolution of colitis. A ECIS wound healing assay. B Lcn-2 quantification (n= 5).
Figure 8 Chart

Wound healing assays and fecal lipocalin-2 quantification demonstrate that TDNPs 2 accelerate resolution of intestinal inflammation. Lcn-2 levels, a sensitive marker of intestinal inflammation, decrease significantly with treatment.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Fig. 9 Biocompatibility evaluation of TDNPs 2. A Vital organs weights (n= 5). B Pro-inflammatory cytokines (n= 5). C Indicators reflected the physiological function of the liver were evaluated. D H&E staining, scale bar: 50 μm
Figure 9 Chart

Biocompatibility evaluation shows no significant changes in vital organ weights, pro-inflammatory cytokines, or liver function indicators in TDNPs 2-treated mice. H&E staining of major organs confirms absence of toxicity.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Fig. 10 TDNPs 2 exerted a protective effect by inactivating the NF-κB pathway. A NF-κB activity evaluation (n= 5). B Phospho-NF-κB p65 expression was evaluated by ELISA assay (n= 5). C The translocation of NF-kB-p65 to the nucleus was assessed by immunofl
Figure 10 Chart

TDNPs 2 exert their protective effect at least partly through inactivation of the NF-kB signaling pathway. Reduced phospho-NF-kB p65 expression and decreased nuclear translocation indicate suppression of this key inflammatory cascade.

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for …

Figure 3
Figure 3 Diagram

Mechanistic diagram illustrating the role of ferroptosis — characterized by iron accumulation, lipid peroxidation, and ROS production — in the pathogenesis of inflammatory bowel disease and its potential as a therapeutic target.

Role of ferroptosis in the pathogenesis and as a therapeutic target of …

Figure 4
Figure 4 Diagram

Mechanistic diagram illustrating the role of ferroptosis — characterized by iron accumulation, lipid peroxidation, and ROS production — in the pathogenesis of inflammatory bowel disease and its potential as a therapeutic target.

Role of ferroptosis in the pathogenesis and as a therapeutic target of …

Figure 5
Figure 5 Diagram

Mechanistic diagram illustrating the role of ferroptosis — characterized by iron accumulation, lipid peroxidation, and ROS production — in the pathogenesis of inflammatory bowel disease and its potential as a therapeutic target.

Role of ferroptosis in the pathogenesis and as a therapeutic target of …

Figure 6
Figure 6 Diagram

Mechanistic diagram illustrating the role of ferroptosis — characterized by iron accumulation, lipid peroxidation, and ROS production — in the pathogenesis of inflammatory bowel disease and its potential as a therapeutic target.

Role of ferroptosis in the pathogenesis and as a therapeutic target of …

Figure 4
Figure 4

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis.

Figure 5
Figure 5

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis.

Figure 6
Figure 6

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis.

Figure 7
Figure 7

Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis.

Figure 5
Figure 5

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress …

Figure 6
Figure 6

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress …

Figure 3 Histological examinations of effects of selenium-containing amino acids on DSS-induced IBD in mice. (A) Representative H&E-stained colon sections of each group (scale bar, 200 μm); (B) Histological scoring of mice treated with selenium-contai
Figure 7

Figure 3 Histological examinations of effects of selenium-containing amino acids on DSS-induced IBD in mice. (A) Representative H&E-stained colon sections of each group (scale bar, 200 μm); (B) Histological scoring …

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress …

Figure 8
Figure 8

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress …

Figure 9
Figure 9

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress …

Figure 6 Effects of selenium-containing amino acids on biochemical test parameters in DSS-induced IBD in mice. Serum levels of (A) ALT, (B) AST, (C) BUN, and (D) CRE in different groups. Differences were assessed via one-way analysis of variance (ANOVA) w
Figure 10

Figure 6 Effects of selenium-containing amino acids on biochemical test parameters in DSS-induced IBD in mice. Serum levels of (A) ALT, (B) AST, (C) BUN, and (D) CRE in different …

Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress …

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