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Figure 3 Vitamin D influence the development of IBD by directly impacting intestinal immunity, microbiota and the intestinal mucosal barrier. Notes: “↑” = increase/up-regulated; “↓” = decrease/down-regulated. Abbreviations: VDR, vitamin D receptor; ZO-1,
Figure 3. Figure 3 Vitamin D influence the development of IBD by directly impacting intestinal immunity, microbiota and the intestinal mucosal barrier. Notes: “↑” = increase/up-regulated; “↓” = decrease/down-regulated. Abbreviations: VDR, vitamin D receptor; ZO-1, zonula occludens-1; ALP, alkaline phosphatase; Treg, regulatory T cell; Th17, T helper 17; Th1, T helper 1; IEC, intestinal epithelial cells; TNF-α, tumor necrosis factor-α; IL-8, interleukin-8; M2, Macrophages 2; M1, Macrophages 1; DC, Dendritic cell; IL-23, interleukin-23; ILC3, innate lymphoid cell 3.

Descrição

Vitamin D's influence on inflammatory bowel disease development is depicted through three interconnected pathways: intestinal immune regulation, microbiota composition, and mucosal barrier integrity.

More Figures from This Paper

Vitamin D's multifaceted role as an immune modulator is discussed, noting that nearly all immune cells express the vitamin D receptor and that deficiency is closely correlated with increased susceptibility to immune-mediated diseases.

Figure 1

Vitamin D's multifaceted role as an immune modulator is discussed, noting that nearly all immune cells express the vitamin D receptor and that deficiency is closely correlated with increased susceptibility to immune-mediated diseases.

diagram
Vitamin D impacts on innate and adaptive immunity are illustrated, showing inhibition of LPS-induced p38 activation, suppression of IL-6 and TNF-alpha by monocytes, and downregulation of TLR-9 expression in immune cells.

Figure 2

Vitamin D impacts on innate and adaptive immunity are illustrated, showing inhibition of LPS-induced p38 activation, suppression of IL-6 and TNF-alpha by monocytes, and downregulation of TLR-9 expression in immune cells.

diagram

Figure 3

Diagram
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Source Paper

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease.

Journal of inflammation research (2022)

PMID: 35662873

DOI: 10.2147/JIR.S363840

Cite This Figure

![Figure 3: Vitamin D's influence on inflammatory bowel disease development is depicted through three interconnected pathways: intestinal immune regulation, microbiota composition, and mucosal barrier integrity.](https://pdfs.citedhealth.com/figures/35662873/300.png)

> Source: Zengrong Wu et al. "The Role of Vitamin D in Immune System and Inflammatory Bowel Disease.." *Journal of inflammation research*, 2022. PMID: [35662873](https://pubmed.ncbi.nlm.nih.gov/35662873/)
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  <img src="https://pdfs.citedhealth.com/figures/35662873/300.png" alt="Vitamin D's influence on inflammatory bowel disease development is depicted through three interconnected pathways: intestinal immune regulation, microbiota composition, and mucosal barrier integrity." />
  <figcaption>Figure 3. Vitamin D's influence on inflammatory bowel disease development is depicted through three interconnected pathways: intestinal immune regulation, microbiota composition, and mucosal barrier integrity.<br>  Source: Zengrong Wu et al. "The Role of Vitamin D in Immune System and Inflammatory Bowel Disease.." <em>Journal of inflammation research</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35662873/">35662873</a></figcaption>
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