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Berberine treatment altered the gut microbiota structure in IBS-derived samples, as shown through diversity indexes and principal coordinate analysis based on weighted UniFrac distances. The Firmicutes-to-Bacteroidetes ratio and phylum-level composition shifted notably after berberine administration compared to vehicle-treated controls.

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![Figure 6: Berberine treatment altered the gut microbiota structure in IBS-derived samples, as shown through diversity indexes and principal coordinate analysis based on weighted UniFrac distances. The Firmicutes-to-Bacteroidetes ratio and phylum-level composition shifted notably after berberine administration compared to vehicle-treated controls.]()

> Source: Jin-Dong Zhang et al. "Berberine alleviates visceral hypersensitivity in rats by altering gut microbiom." *Acta pharmacologica Sinica*, 2021. PMID: [33558654](https://pubmed.ncbi.nlm.nih.gov/33558654/)
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  <img src="" alt="Berberine treatment altered the gut microbiota structure in IBS-derived samples, as shown through diversity indexes and principal coordinate analysis based on weighted UniFrac distances. The Firmicutes-to-Bacteroidetes ratio and phylum-level composition shifted notably after berberine administration compared to vehicle-treated controls." />
  <figcaption>Figure 6. Berberine treatment altered the gut microbiota structure in IBS-derived samples, as shown through diversity indexes and principal coordinate analysis based on weighted UniFrac distances. The Firmicutes-to-Bacteroidetes ratio and phylum-level composition shifted notably after berberine administration compared to vehicle-treated controls.<br>  Source: Jin-Dong Zhang et al. "Berberine alleviates visceral hypersensitivity in rats by altering gut microbiom." <em>Acta pharmacologica Sinica</em>, 2021. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33558654/">33558654</a></figcaption>
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