Eliminating ROS and Alleviating Inflammation to Restore the Integrity of Intestinal Epithelium in DSS-Induced Ulcerative Colitis by a pH-Responsive Delivery System of Curcumin.

Ruili Li, Ye Xiao, Rui Wu, Zhaoxin Lu, Fanqiang Meng et al.

Other Journal of agricultural and food chemistry 2025 3 citations

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Study Design

Study Type: Other
Population: DSS-induced UC mouse model

Intervention: Eliminating ROS and Alleviating Inflammation to Restore the Integrity of Intestinal Epithelium in DSS-Induced Ulcerative Colitis by a pH-Responsive Delivery System of Curcumin. None
Comparator: DSS-induced UC mice without CURDNPs
Primary Outcome: UC symptoms, ROS, and intestinal barrier integrity
Effect Direction: Positive
Risk of Bias: High

Abstract

The current consensus is that combating reactive oxygen species (ROS) and implementing site-specific drug delivery are effective strategies for managing ulcerative colitis (UC). Herein, ferulic acid (FA) was used to fabricate curcumin (CUR) derivative polymer nanoparticles (CURDNPs) as a delivery vehicle for CUR, forming CURDNPs@CUR. This system enhances the dispersion, bioavailability, UV protection, and controlled-release performance of CUR while also improving its ROS-eliminating activity. In dextran sulfate sodium salt (DSS)-treated mice, CURDNPs@CUR delivers curcumin specifically to the colon, boosts antioxidant enzyme activity, and significantly ameliorates colon histopathology. It reduces the expression of pro-inflammatory cytokine genes (TNFα, NLRP3, and iNOS) and restores intestinal epithelial integrity by decreasing intestinal permeability and enhancing the expression of tight junction proteins (TJPs), including ZO-1, Occludin-1, and Claudin-1. These findings suggest the successful synthesis of a targeted/antioxidant CUR delivery vehicle for synergistic UC therapy via ROS elimination, barrier repair, and anti-inflammation.

TL;DR

These findings suggest the successful synthesis of a targeted/antioxidant CUR delivery vehicle for synergistic UC therapy via ROS elimination, barrier repair, and anti-inflammation.

Used In Evidence Reviews

B Curcumin for Ulcerative Colitis (UC)

Eliminating ROS and Alleviating Inflammation to Restore the Integrity of Intestinal Epithelium in DSS-Induced Ulcerative Colitis by a pH-Responsive Delivery System of Curcumin.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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