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Role of Vitamin D in Inflammatory Bowel Disease.

Berkeley N Limketkai, Gerard E Mullin, David Limsui, Alyssa M Parian
Review Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2017 55 citations
PubMed DOI
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Study Design

Study Type
Review
Population
Inflammatory bowel disease patients
Intervention
Role of Vitamin D in Inflammatory Bowel Disease. None
Comparator
None
Primary Outcome
None
Effect Direction
Mixed
Risk of Bias
Unclear

Abstract

Vitamin D is a secosteroid hormone that possesses immunomodulatory properties and has been demonstrated to potentially influence inflammatory bowel disease (IBD) pathogenesis and activity. Epidemiologic data have associated vitamin D deficiency with an increased risk of IBD, hospitalizations, surgery, and loss of response to biologic therapy. Conversely, IBD itself can lead to vitamin D deficiency. This bidirectional relationship between vitamin D and IBD suggests the need for monitoring and repletion of vitamin D, as needed, in the IBD patient. This review discusses the role of vitamin D in IBD and provides practical guidance on vitamin D repletion.

TL;DR

The bidirectional relationship between vitamin D and IBD suggests the need for monitoring and repletion of vitamin D, as needed, in the IBD patient, and practical guidance on vitamin D repletions is provided.

Used In Evidence Reviews

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