Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib.

Bohuslav Melichar, Markéta Kašparová, Hana Kalábová, Josef Dvorák, Radomír Hyšpler et al.

Other Journal of nutritional science and vitaminology 2010 2 citations

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Study Design

Study Type: Other
Population: cancer patients

Intervention: Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib. None
Comparator: None
Primary Outcome: tumor growth
Effect Direction: Neutral
Risk of Bias: Unclear

Abstract

Administration of imatinib is the therapy of choice in patients with advanced (inoperable) or metastatic gastrointestinal stromal tumors (GIST). Gastrointestinal toxicity is one of the most common side effects of anticancer therapy, including imatinib. Measurement of intestinal permeability represents a method of noninvasive laboratory assessment of gastrointestinal toxicity. We have measured intestinal permeability (by determining absorption of lactulose, mannitol and xylose), vitamin A absorption and serum alpha-tocopherol in 16 patients with advanced/metastatic GIST treated with imatinib. Lactulose/mannitol and lactulose/xylose ratios as well as parameters of vitamin A absorption did not change significantly during the treatment, but a significant decrease of alpha-tocopherol was observed. We conclude that, in contrast to most other anticancer agents studied so far, imatinib does not have an effect on intestinal permeability. No effect on vitamin A absorption was observed, but serum alpha-tocopherol decreased significantly during the treatment.

TL;DR

It is concluded that, in contrast to most other anticancer agents studied so far, imatinib does not have an effect on intestinal permeability.

Used In Evidence Reviews

C Vitamin A for Increased Intestinal Permeability (Leaky Gut)

Intestinal permeability, vitamin A absorption and serum alpha-tocopherol in gastrointestinal stromal tumor patients treated with imatinib.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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