Systematic review of randomised controlled trials: probiotics for functional constipation.

Anna Chmielewska, Hania Szajewska

Systematic Review World journal of gastroenterology 2010 276 citations

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Study Design

Study Type: Systematic Review
Sample Size: 377
Population: None

Intervention: Systematic review of randomised controlled trials: probiotics for functional constipation. None
Comparator: control group
Primary Outcome: None
Effect Direction: Positive
Risk of Bias: Low

Abstract

AIM: To systematically evaluate and update evidence on the efficacy and safety of probiotic supplementation for the treatment of constipation. METHODS: The MEDLINE, EMBASE, CINAHL, and Cochrane Library databases were searched in May 2009 for randomised controlled trials (RCTs) performed in paediatric or adult populations related to the study aim. RESULTS: We included five RCTs with a total of 377 subjects (194 in the experimental group and 183 in the control group). The participants were adults (three RCTs, n = 266) and children (two RCTs, n = 111) with constipation. In adults, data suggests a favourable effect of treatment with Bifidobacterium lactis DN-173 010, Lactobacillus casei Shirota, and Escherichia coli Nissle 1917 on defecation frequency and stool consistency. In children, L. casei rhamnosus Lcr35, but not L. rhamnosus GG, showed a beneficial effect. CONCLUSION: Until more data are available, we believe the use of probiotics for the treatment of constipation condition should be considered investigational.

TL;DR

Until more data are available, it is believed the use of probiotics for the treatment of constipation condition should be considered investigational.

Used In Evidence Reviews

B Bifidobacterium lactis for Chronic Constipation

Systematic review of randomised controlled trials: probiotics for functional constipation.

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Study Design

Abstract

TL;DR

Used In Evidence Reviews

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