Mechanisms of action of zinc in acute diarrhea.

Roberto Berni Canani, Vittoria Buccigrossi, Annalisa Passariello

Review Current opinion in gastroenterology 2011 59 件の引用

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Study Design

研究タイプ: In Vitro
対象集団: None

介入: Mechanisms of action of zinc in acute diarrhea. None
比較対照: None
主要アウトカム: oxidative stress
効果の方向: Mixed
バイアスリスク: Unclear

Abstract

PURPOSE OF REVIEW: For over a decade, the importance of zinc in the treatment of acute diarrhea has been recognized. More recently, the mechanisms of action of zinc are becoming clearer. This review is focused on the new evidence on the mechanisms of action of zinc in acute diarrhea. RECENT FINDINGS: The vast majority of data derive from in-vitro studies using intestinal cell lines or from animal model. The positive action by zinc in acute diarrhea derives from a regulation of intestinal fluid transport, mucosal integrity, immunity, gene expression, and oxidative stress. A complex homeostatic network is also able to regulate zinc status at cellular and extracellular level. SUMMARY: All these data support the use of zinc in the treatment of acute diarrhea, but further clinical studies are needed to explore the selective effects of zinc against specific pathogens responsible for diarrhea.

要約

Evidence from in-vitro studies and clinical studies support the use of zinc in the treatment of acute diarrhea, but further clinical studies are needed to explore the selective effects of zinc against specific pathogens responsible for diarrhea.

Used In Evidence Reviews

A Zinc ： Acute Diarrhea

Mechanisms of action of zinc in acute diarrhea.

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Study Design

Abstract

要約

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